CHIR-98014

1) Cat. No.: TRC-C292100; 2) Chemical Name: CHIR-98014; 3) CAS No.: 556813-39-9; 4) Mol. Formula: C20H17Cl2N9O2; 5) Mol. Weight: 486.31; 6) Packing Size: 5mg / 50mg; 7) Appearence: Yellow Solid; 8) Application Notes: A glycogen synthase kinase-3 (GSK-3) inhibitor. Effects of GSK inhibitors on p-tau, GSK-3β activities and cell death were measured in a human neuronal cell line (LUHMES). Lithium and CHIR98014 reduced tau phosphorylation (Ser396) in the cortex and hippocampus. Inhibition of GSK-3 is recently regarded as one of the viable approaches to therapy for Alzheimer's disease, cancer, diabetes mellitus, osteoporosis, and bipolar mood disorder. ; 9) Synonym: N6-[2-[[4-(2,4-Dichlorophenyl)-5-(1H-imidazol-2-yl)-2-pyrimidinyl]amino]ethyl]-3-nitro- 2,6-pyridinediamine; ; 10) Solubility: DMSO, Methanol; 11) Storage condition: Refrigerator; 12) References: Aardema, M., et al.: Mutat. Res., 410, 3 (1998), Coghlan, M., et al.: Chem. Biol., 7, 793 (2000), Ring, D., et al.: Diabetes, 52, 588 (2003), Ougolkov, A., et al.: Cancer Res., 65, 2076 (2005), Armstrong, V., et al.: J. Biol. Chem., 282, 20715 (2007), Guo, Z., et al.: Blood, 109, 5463 (2007),