(E,E)-Bis(2-hydroxybenzylidene

1) Cat. No.: TRC-B443810; 2) Chemical Name: (E,E)-Bis(2-hydroxybenzylidene)acetone (2-HBA); 3) CAS No.: 131359-24-5; 4) Mol. Formula: C17H14O3; 5) Mol. Weight: 266.29; 6) Packing Size: 25mg / 250mg; 7) Appearence: ; 8) Application Notes: (E,E)-Bis(2-hydroxybenzylidene)acetone (2-HBA) is a synthetic analogue of curcumin that displays strong NAD(P)H:quinone reductase (NQO1) inducer potency in Hepa 1c1c7 cells. 2-HBA, a double Michael reaction acceptor, can directly modify cysteine sulfhydryl groups in Keap1 and consequently suppress Nrf2 ubiquitination which in turn enhances the expression of antioxidative and cytoprotective enzymes. 2-HBA has also been shown to cause G2/M cell cycle arrest and p53-independent, caspase 3-mediated apoptosis.; 9) Synonym: (1E,4E)-1,5-Bis(2-hydroxyphenyl)-1,4-pentadien-3-one; 2-HBA; (E,E)-1,5-Bis(2-hydroxyphenyl)-1,4-pentadien-3-one; ; 10) Solubility: ; 11) Storage condition: ; 12) References: Perjesi, P. et al.: In Vivo, 20, 141 (2006); Magesh, S. et al.: Med. Res. Rev., 32, 687 (2012); Dinkova-Kostova, A.T. et al.: Cancer Lett., 245, 341 (2007);