ABT 737-d8

1) Cat. No.: TRC-A112552; 2) Chemical Name: ABT 737-d8; 3) CAS No.: ; 4) Mol. Formula: C42H37D8ClN6O5S2; 5) Mol. Weight: 821.48; 6) Packing Size: 1mg / 10mg; 7) Appearence: Yellow Solid; 8) Application Notes: A selective inhibitor of BCL-2, in small cell lung cancer. ABT-737 induced dramatic regressions in tumors derived from some SCLC cell lines. ; 9) Synonym: 4-[4-[(4’-Chloro[1,1’-biphenyl]-2-yl)methyl]-1-piperazinyl]-N-[[4-[[(1R)-3-(dimethylamino)-1-[(phenylthio)methyl]propyl]amino]-3-nitrophenyl]sulfonyl]benzamide-d8;; 10) Solubility: DMSO; 11) Storage condition: -20°C Freezer; 12) References: Ikegaki, N., et al.: Cancer Res., 54, 6 (1994), Kaiser, U., et al.: Lung Cancer, 15, 31 (1996), Rudin, C., et al.: J. Clin. Oncol., 22, 1110 ( 2004), Konopleva, M., et al.: Cancer Cell, 10, 375 (2006), Trudel, S., et al.: Clin. Cancer Res., 13, 621 (2007),