K016126P Anti-Phospho-JAK1(Tyr

【抗体靶点简介】

Janus kinase 1 (JAK1)， is a member of a new class of protein-tyrosine kinases (PTK) characterized by the presence of a second phosphotransferase-related domain immediately N-terminal to the PTK domain. The second phosphotransferase domain bears all the hallmarks of a protein kinase， although its structure differs significantly from that of the PTK and threonine/serine kinase family members. JAK1 is a large， widely expressed membrane-associated phosphoprotein. JAK1 is involved in the interferon-alpha/beta and -gamma signal transduction pathways. The reciprocal interdependence between JAK1 and TYK2 activities in the interferon-alpha pathway， and between JAK1 and JAK2 in the interferon-gamma pathway， may reflect a requirement for these kinases in the correct assembly of interferon receptor complexes. These kinases couple cytokine ligand binding to tyrosine phosphorylation of various known signaling proteins and of a unique family of transcription factors termed the signal transducers and activators of transcription， or STATs.

【实验操作视频参考】

Western blot实验参考操作流程

Immunohistochemistry实验参考操作流程

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