p53 Tumor Suppressor Protein A

类别: Antibodies

产品子类型: Primary Antibody

描述: p53 is a tumor suppressor gene expressed in a wide variety of tissue types and is involved in regulating cell growth, replication, and apoptosis. It binds to MDM2, SV40 T antigen and human papilloma virus E6 protein. Positive nuclear staining with p53 antibody has been reported to be a negative prognostic factor in breast carcinoma, lung carcinoma, colorectal, and urothelial carcinoma. Anti-p53 positivity has also been used to differentiate uterine serous carcinoma from endometrioid carcinoma as well as to detect intratubular germ cell neoplasia. Mutations involving p53 are found in a wide variety of malignant tumors, including breast, ovarian, bladder, colon, lung, and melanoma.

克隆号: TP53/7002R

应用稀释比例: Flow cytometry: 1-2ug/million cells,Immunohistochemistry (FFPE): 1-2ug/ml

应用说明: Optimal dilution of the p53 Tumor Suppressor Protein antibody should be determined by the researcher.

免疫原: Recombinant human full-length TP53 protein was used as the immunogen for the p53 Tumor Suppressor Protein antibody.

防腐剂: 1 mg/ml in 1X PBS; rAlbumin free, sodium azide free

纯化方法: Protein A/G affinity

研究领域: Cancer Biology

UniProt ID: P04637

保存条件: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

备注: For research use only.