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- 文献和实验
- 技术资料
- 保存条件：
2-8度
- 保质期：
1年
- 英文名：
HIV-1 env- His
- 库存：
999
- 供应商：
上海淳麦生物
- 规格：
/5ug/20ug/1mg
Recombinant HIV-1 Envelope， His Tag
英文简称:
HIV-1 env- His
中文名称:
重组HIV-1包膜蛋白，His标签
背景资料:
HIV (Human Immunodeficiency Virus) （HIV） is a retrovirusthat can lead to a condition in which the immune systembegins to fail， leading to opportunistic infections. HIV primarily infects vital cells in the humanimmune systemsuch as helper T cells（specifically CD4+ T cells）， macrophagesand dendritic cells. HIV infection leads to low levels of CD4+ T cells through thrHIV-1 envelope His Tag Recombinant-is an E. Coli-derived 74.18 kDa protein that contains immunodominant regions of gp120 C-terminus and gp41 N-terminus of the HIV1 and having 6X His tag protein on the N-terminus. main mechanisms: firstly， direct viral killing of infected cells； secondly， increased rates of apoptosisin infected cells； and thirdly， killing of infected CD4+ T cells by CD8 cytotoxic lymphocytesthat recognize infected cells. When CD4+ T cell numbers decline below a critical level， cell-mediated immunityis lost， and the body becomes progressively more susceptible to opportunistic infections. HIV was classified as a member of the genus Lentivirus， part of the family of Retroviridae. Lentiviruses have many common morphologies and biological properties. Many species are infected by lentiviruses， which are characteristically responsible for long-duration illnesses with a long incubation period. Lentiviruses are transmitted as single-stranded， positive-sense， enveloped RNA viruses. Upon entry of the target cell， the viral RNA genomeis converted to double-stranded DNAby a virally encoded reverse transcriptasethat is present in the virus particle. This viral DNA is then integrated into the cellular DNA by a virally encoded integraseso that the genome can be transcribed. Once the virus has infected the cell， two pathways are possible: either the virus becomes latentand the infected cell continues to function， or the virus becomes active and replicates， and a large number of virus particles are liberated that can then infect other cells.
产品描述:
HIV-1 envelope His Tag Recombinant-is an E. Coli-derived 74.18 kDa protein that contains immunodominant regions of gp120 C-terminus and gp41 N-terminus of the HIV1 and having 6X His tag protein on the N-terminus.
来源宿主:
大肠杆菌中重组表达
溶解建议:
提供的重组HIV-1包膜蛋白，His标签产品为无菌的无色透明溶液形式.该产品已溶解在含0.02% NaN3 (防腐剂)的20mM 碳酸钠缓冲液（pH 9.6）.
保存建议：
HIV-1 Envelope protein is shipped at ambient temperature. Upon arrival， Store at -20℃ Stable for Five years frozen. One month in solution at room temperature.
应用领域：
重组HIV-1包膜蛋白，His标签产品可广泛应用于功能研究、蛋白互作研究、ELISA检测、Western Blot、免疫组化等生物医学研究领域。
关键词：
重组HIV-1包膜蛋白，His标签、Recombinant HIV-1 Envelope， His Tag、HIV-1 env- His、重组蛋白、原核表达、His标签、CMBIO、淳麦生物
其他简介：
CMBIO
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文献和实验The HIV-1 entry receptors are CD4 and a chemokine receptor (CCR5 or CXCR4). In addition it has recently been demonstrated that HIV-1 gp120 binds to and signals through integrin α4 β7 , the gut-homing receptor (Arthos et al., Nat Immunol
A Cell-Cell Fusion Assay to Monitor HIV-1 Env Interactions with Chemokine Receptors
for triggering the fusion-inducing conformational change in the Env protein have been only recently identified, permitting the study of HIV-1 Env-mediated membrane fusion in much greater detail (for review, see 1 ). These molecules, termed coreceptors
不同的HIV-1亚型在编码包膜蛋白的env基因的高度变异致使其包膜蛋白氨基酸序列改变，从而导致病毒对免疫攻击的敏感性改变使其能逃脱免疫系统的监视。Henderson等人根据对百余种不同株型的HIV-1gp120的一级结构的分析发现，它的V3环36个氨基酸残基中，只有在环基底部的2个半胱氨酸的残基及附近的氨基酸残基和顶部的GPG保持不变，其它部分则变异很大。有研究表明不同地区分离得到HIV-1毒株间的gp160蛋白氨基酸序列有20%以上的变异率，不同亚型遗传及血清学上反应存在明显差异
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