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- 文献和实验
- 技术资料
- 保存条件：
2-8度
- 保质期：
1年
- 英文名：
RHEB
- 库存：
999
- 供应商：
上海淳麦生物
- 规格：
/5ug/20ug/1mg
Recombinant Human Ras Homolog Enriched in Brain
英文简称:
RHEB
中文名称:
重组人富集于脑Ras同系物
背景资料:
RHEB is part of the Ras & GTPase superfamily that was originally identified as an immediate-early gene in brain but is also widely expressed in other tissues. RHEB encodes a lipid-anchored， cell membrane protein with five repeats of the RAS-related GTP-binding region. RHEB is necessary in regulation of growth and cell cycle progression due to its role in the insulin/TOR/S6K signaling pathway. RHEB has GTPase activity and shuttles betwRHEB Human Recombinant produced in E.Coli is a single， non-glycosylated polypeptide chain containing 197 amino acids （1-181 amino acids） and having a molecular mass of 21.7 kDa. The RHEB is fused to T7-tag at N-terminus （16 a.a.） and is purified by standard chromatography techniques.n a GDP-bound form and a GTP-bound form， and farnesylation of the protein is required for this activity. RHEB induces oncogenic transformation. RHEB overexpression accelerates lymphomagenesis and is associated with prostate cancer. RHEB can cytopathologically distinguish betwRHEB Human Recombinant produced in E.Coli is a single， non-glycosylated polypeptide chain containing 197 amino acids （1-181 amino acids） and having a molecular mass of 21.7 kDa. The RHEB is fused to T7-tag at N-terminus （16 a.a.） and is purified by standard chromatography techniques.n fibroadenoma from malignant breast carcinomas which is considered as a secondary diagnostic tool. RHEB has a central role in the regulation of the Ras/B-Raf/C-Raf/MEK signaling network.
产品描述:
RHEB Human Recombinant produced in E.Coli is a single， non-glycosylated polypeptide chain containing 197 amino acids （1-181 amino acids） and having a molecular mass of 21.7 kDa. The RHEB is fused to T7-tag at N-terminus （16 a.a.） and is purified by standard chromatography techniques.
来源宿主:
大肠杆菌中重组表达
溶解建议:
Sterile Filtered colorless solution. The RHEB protein solution contains 20mM Tris pH-8， 1mM DTT and 10% glycerol.
保存建议：
RHEB although stable 4℃ for 4 weeks， should be stored desiccated below -18℃. For long term storage it is recommended to add a carrier protein （0.1% HSA or BSA）. Please prevent freeze-thaw cycles.
应用领域：
重组人富集于脑Ras同系物产品可广泛应用于功能研究、蛋白互作研究、ELISA检测、Western Blot、免疫组化等生物医学研究领域。
关键词：
重组人富集于脑Ras同系物、Recombinant Human Ras Homolog Enriched in Brain、RHEB、重组蛋白、多肽、原核表达、CHO表达、标签蛋白
其他简介：
CMBIO
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文献和实验癌症、糖尿病与心血管疾病。 小G蛋白Rheb(Ras homolog enriched in brain)是mTOR信号通路 的关键调节蛋白，虽然调控Rheb的GTP水解酶激活蛋白(GAP)很早被发现，但是其鸟嘌呤交换因子(GEF)一直没有被鉴定出来。最近有实验表明果蝇的TCTP(translationally controlled tumor protein) 对TOR信号传导通路有调控作用，有可能是Rheb的GEF。小鼠和拟兰芥中的遗传学实验表明TCTP对于细胞生长也有重要
上新：细胞治疗原料扩容:GMP级重组人VEGF165 - 血管再生核心因子
细胞凋亡、提升细胞存活率，同时调控细胞代谢稳态，为血管内皮细胞持续增殖、血管结构稳定形成提供基础，也是缺血组织修复、细胞保护的核心通路。 02 MAPK/ERK信号通路（促增殖、促迁移） 受体磷酸化后启动Ras-Raf-MEK-ERK级联反应，激活ERK1/2通路。主要负责驱动血管内皮细胞快速增殖、定向迁移，调控细胞周期进程，是诱导血管芽生成、管状结构形成、新生血管重塑的核心信号通路，直接决定血管新生效率与质量。 03
Tissue-Specific Ablation of Tsc1 in Pancreatic Beta-Cells
Tuberous sclerosis complex 1 (TSC1) is a tumor suppressor that associates with TSC2 to inactivate Rheb, thereby inhibiting signaling by the mammalian target of rapamycin (mTOR) complex 1 (mTORC1). mTORC1 stimulates cell growth by promoting
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