重组人白介素-32α(IL 32A)

产品英文名称：
Recombinant Human IL-32 alpha

英文简称:
IL 32A

中文名称:
重组人白介素-32α

背景资料:
IL-32 is part of the cytokine family and contains a tyrosine sulfation site，3 potential N-myristoylation sites，multiple putative phosphorylation sites，and an RGD cell-attachment sequence. IL-32 expression is elevated after the activation of T-cells by mitogens or the activation of NK cells by IL-2. IL-32 induces the production of TNF-a from macrophage cells. IL-32 pro-inflammatory pathway is activated in response to influenza A virus infection. Dysregulation of IL-32 in myelodysplastic syndrome and chronic myelomonocytic leukemia modulates apoptosis and impairs NK function. Induction of TNF，IL-1beta，and IL-6 by IL-32 is intervened by p38-MAPK. IL-32 induced monocyte-to-macrophage di大肠杆菌中重组表达erentiation is mediated through nonapoptotic，caspase-3-dependent mechanisms. IL32 plays an important role in the pathogenesis of rheumatoid arthritis. IL-32 is involved in activation-induced cell death in T cells，through its intracellular actions. IL-32 is a cell-associated proinflammatory cytokine，which is particularly stimulated by mycobacteria through a caspase-1- and IL-18-dependent production of interferon gamma. IL-32 is associated with TNF-a，IL-1beta，and IL-18. IL32 is involved in human rheumatoid arthritis and is a novel target in autoimmune diseases.

产品描述:
人白介素-32α重组蛋白是在大肠杆菌中重组表达的，是一条单链、非糖基化的多肽链，包含有131个氨基酸，分子量为14.9kDa.
来源宿主:
大肠杆菌中重组表达

溶解建议:
提供的人白介素-32α（IL 32A）产品为过滤灭菌的白色冻干粉末；该冻干粉末是从含1mg/ml人白介素-32α（IL 32A）的50mM磷酸钠缓冲液（pH 7.5）中冻干产生的.我们建议加无菌的18MΩ-cm水以配制工作储存液到100ug/ml，后继实验过程中可根据实验要求进一步稀释.

保存建议：
人白介素-32α（IL 32A）在室温可保存3周，或置于-18℃冻存用于长期保存.重新溶解后可以在4℃冷藏保存至少2-7天；如果想延长保存时间，建议分装后置于-18℃冻存.请避免反复冻融.
应用领域：
重组人白介素-32α产品可广泛应用于免疫学研究、细胞信号传导研究、抗病毒研究、免疫调节研究、免疫调节研究、炎症研究、功能研究、蛋白互作研究、ELISA检测、Western Blot、免疫组化等生物医学研究领域。

关键词：
重组人白介素-32α、Recombinant Human IL-32 alpha、IL 32A、重组蛋白、多肽、细胞因子、干扰素、白介素

其他简介：

 
CMBIO