p38 Antibody (PerCP) 抗体，orb151

类别: Antibodies

描述: Rabbit polyclonal to p38 (PerCP). The MAPK (mitogen activated protein kinase) comprises a family of ubiquitous praline-directed, protein-serine/threonine kinases which signal transduction pathways that control intracellular events including acute responses to hormones and major developmental changes in organisms. This super family consists of stress activated protein kinases (SAPKs); extracellular signal-regulated kinases (ERKs); and p38 kinases, each of which forms a separate pathway. The kinase members that populate each pathway are sequentially activated by phosphorylation. Upon activation, p38 MAPK/SAPK2alpha translocates into the nucleus where it phosphorylates one or more nuclear substrates, effecting transcriptional changes and other cellular processes involved in cell growth, division, differentiation, inflammation, and death. Specifically p38 always acts as a pro-apoptotic factor with its activation leading to the release of cytochrome c from mitochondria and cleavage of caspase 3 and its downstream effector, PARP. p38 MAPK is activated by a variety of chemical stress inducers including hydrogen peroxide, heavy metals, anisomycin, sodium salicylate, LPS, and biological stress signals such as tumor necrosis factor, interleukin-1, ionizing and UV irradiation, hyperosmotic stress and chemotherapeutic drugs. As a result, p38 alpha has been widely validated as a target for inflammatory disease including rheumatoid arthritis, COPD and psoriasis and has also been implicated in cancer, CNS and diabetes..

别名: CSAID Binding protein 1, CSBP1, CSBP2, EXIP, MAP kinase MXI2, MAPkinase p38alpha, MAPK14, p38 ALPHA, p38 MAP kinase, p38 mitogen activated protein kinase, RK, SAPK 2A, Stress activated protein kinase 2A

应用稀释比例: WB (1:1000), ICC/IF (1:100), IP (1:250)

应用说明: A 1:1000 dilution was sufficient for detection of p38 in 20 µg of HeLa cell lysate by ECL immunoblot analysis.

免疫原: A 20 residue synthetic peptide based on the human p38 with the cysteine residue added and coupled to KLH

分子量: 43kDa

防腐剂: 95.46mM Phosphate, 2.48mM MES and 2mM EDTA

纯化方法: Peptide Affinity Purified

特异性: Detects ~43kDa.

研究领域: Cancer Biology, Protein Biochemistry, Signal Transduction

UniProt ID: Q16539

NCBI 参考序列: NP_001306.1

Entrez 基因 ID: 1432

保存条件: Conjugated antibodies should be stored according to the product label

备注: For research use only.