Alpha B Crystallin Antibody (P

类别: Antibodies

描述: Rabbit polyclonal to Alpha B Crystallin (PerCP). The alpha-crystallins are major water-soluble lens structural proteins of the vertebrate eye that are related to the small heat shock protein family. The alpha-crystallins possess structural and functional similarities with Hsp25 and Hsp27. Mammalian lens cystallins are divided into alpha, beta and gamma families. Alpha and beta families are further divided into acidic and basic groups (Alpha-A and Alpha-B respectively). In the lens, alpha-crystallin primarily functions to maintain proper refractive index, however it can also function as a molecular chaperone that binds to the denatured proteins, keeping them in solution and thereby maintaining the translucency of the lens. When cellular stress occurs, alpha-crystallin enters its phosphorylated state and may serve a structural control function and play a role in protein maintenance. In addition to their interaction with proteins, alpha-crystallins also interact with native molecules such as membrane proteins, Golgi matrix protein, structural proteins, nuclear proteins and DNA (3, 4, 5, 6, and 7). Two other functions are an autokinase activity and participation in the intracellular architecture, and it has also been proven that both alpha-A and B prevent apoptosis by inhibiting caspases. Specifically, alpha-B cystallin is found in many cells and organs outside the lens, and alpha B is overexpressed in several neurological disorders and in cell lines under stress conditions..

别名: Alpha B Crystallin, CRYAB, CRYA2, HSPB5, Heat Shock Protein Beta-5, Heat Shock Protein Family B Member 5, Alpha-Crystallin B Chain, Crystallin Alpha B, Alpha (B)-Crystallin, HEL-S-101, CMD1II, CTPP2, CTRCT16, MFM2, Rosenthal Fiber Component, Epididymis Secretory Protein Li 101, Heat-Shock 20 KD Like-Protein, Renal Carcinoma Antigen NY-REN-27

应用稀释比例: WB (1:5000), ICC/IF (1:120)

应用说明: A 1:5000 dilution was sufficient for detection of alpha B crystallin in 20 µg of HeLa cell lysate by ECL immunoblot analysis.

免疫原: Synthetic peptide corresponding to human alpha B crystallin conjugated to KLH

分子量: 22kDa

防腐剂: 95.46mM Phosphate, 2.48mM MES and 2mM EDTA

纯化方法: Affinity Purified

特异性: Detects ~22kDa. Does not cross-react with αA-crystallin.

研究领域: Cancer Biology, Cell Biology, Neuroscience, Protein Biochemistry, Signal Transduction

UniProt ID: P02511

NCBI 参考序列: NP_001876.1

Entrez 基因 ID: 1410

保存条件: Conjugated antibodies should be stored according to the product label

备注: For research use only.