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- ￥7254
- Biorbyt
- orb758830
- 英国
- 2026年07月27日
- FA, FC, IF, WB
- Mouse
- Mouse
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- 文献和实验
- 技术资料
- 抗体名：
Anti-CD20 [18B12] 抗体
- 抗体英文名：
Anti-CD20 [18B12]
- 靶点：
CD20
- 浓度：
1 mg/ml
- 应用范围：
FA, FC, IF, WB
- 宿主：
Mouse
- 适应物种：
Mouse
- 保质期：
12 months from date of receipt.
- 抗原来源：
详询
- 目录编号：
orb758830
- 级别：
科研
- 库存：
99
- 供应商：
Biorbyt
- 标记物：
Unconjugated
- 克隆性：
Monoclonal
- 保存条件：
详询
- 亚型：
Mouse IgG
- 免疫原：
详询
- 规格：
0.2 mg
描述: Rabbit monoclonal antibody to CD20
克隆号: 18B12
别名: Ly-44; B-cell differentiation antigen Ly-44; B-lymphocyte antigen CD20; CD20; CD20 antigen; Lymphocyte antigen 44; Membrane-spanning 4-domains subfamily A member 1; membrane-spanning 4-domains, subfamily A, member 2
免疫原: This antibody was generated by immunizing CD20−/− mice with CD20-transfected cell lines (300.18 and 70Z3) and CD20-peptide-keyhole limpet hemocyanin conjugate.
防腐剂: PBS with 0.02% Proclin 300.
纯度: Purified
特异性: This antibody is specific for murine CD20, which is a cell surface 33-37 (depending on the degree of phosphorylation) kDa non-glycosylated surface phosphoprotein expressed on mature and most malignant B cells, but not stem cells or plasma cells. Low number of the CD20 has been also detected on a subpopulation of T lymphocytes and it can be expressed on follicular dendritic cells. Its expression on B cells is synchronous with the expression of surface IgM. CD20 regulates transmembrane calcium conductance (probably functioning as a component of store-operated calcium channel), cell cycle progression and B-cell proliferation. CD20 serves as a useful target for antibody-mediated therapeutic depletion of B cells, as it is expressed at high levels on most B-cell malignancies, but does not become internalized or shed from the plasma membrane following mAb treatment.
研究领域: Immunology & Inflammation
UniProt ID: P19437
保存条件: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
备注: For research use only.
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文献和实验monoclonal anti-HA 16B12 (MMS101R, BAbCo, used at 1:200 to 1:1000 dilution) mouse monoclonal anti-HA 12CA5 (12CA5, Boehringer, used at 1:200 dilution) rabbit polyclonal anti-HA (RS1010C, BAbCo, used at 1:200 dilution) Cy3-conjugated affinity
Anti-HA Immunocytology The multiple copies of the HA epitope present in the HAT tag can be detected by the mouse monoclonal antibodies 12CA5 (Boehringer) and 16B12 (MMS101R; BAbCO, Richmond, California) (see Table 1). On Western blots
，继续培养18小时，收集细胞，闪烁仪记数。（3） Fab诱导Raji细胞凋亡实验按1106细胞/孔接种24孔培养板，加入Fab溶液终浓度为50g/ml， 以PBS为空白对照，37℃，5%CO2培养24小时，2600g离心10分钟，收集细胞，PBS洗2次，加70%的乙醇混匀，4℃，固定一小时，2600g离心10分钟，弃上清，PBS洗2次，加20l PI室温避光放置15分钟，FACS测定。二、结果与讨论1、嵌合抗CD20 Fab对Raji 细胞生长的影响人体对鼠源性抗体的免疫反应（HAMA）以及抗体
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