Rat β-NGF Assay

Nerve growth factor (NGF) is a neurotrophic protein encoded by the NGF gene, essential for the survival, development, and maintenance of sympathetic and sensory neurons. It signals through two receptors: high-affinity TrkA (tropomyosin receptor kinase A) and low-affinity p75 neurotrophin receptor (p75NTR). NGF binding to TrkA activates PI3K/Akt, MAPK, and PLC-γ pathways, promoting neuronal growth and survival, while p75NTR can modulate apoptosis or survival depending on cellular context. Beyond the nervous system, NGF is involved in inflammation, immune responses, and angiogenesis. Elevated NGF levels are associated with chronic pain, asthma, arthritis, and various cancers. Anti-NGF antibodies (e.g., tanezumab) have been developed for pain management. NGF also plays a role in wound healing and tissue repair.