相关产品推荐更多 >
万千商家帮你免费找货
0 人在求购买到急需产品
相关阅读
细胞污染识别与处理全攻略:5 种常见类型+关键误区Cytoscape 教程来了!快速实现顶刊同款通路网络图五大应用案例:Mustang Q 膜层析应用全解析1 个小工具,一次性搞定流程图、质粒图谱和信号通路图- 详细信息
- 文献和实验
- 技术资料
- 免疫原:
inquire
- 亚型:
Human IgG1 - kappa
- 形态:
Powder
- 保存条件:
Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
- 克隆性:
Monoclonal
- 标记物:
Unconjugated
- 适应物种:
Human
- 级别:
Research use only
- 库存:
In Stock
- 供应商:
缔码生物(武汉)科技有限公司
- 宿主:
Humanized
- 应用范围:
ELISA; Flow Cyt
- 浓度:
详见COA
- 靶点:
CLDN6
- 抗体英文名:
Anti-CLDN6 (IMAB027) mAb
- 抗体名:
Anti-CLDN6 (IMAB027) mAb
- 规格:
50μg
| 产品类型 | Biosimilar reference antibodies |
|---|---|
| 靶点 | CLDN6 |
| Uniprot ID | P56747 |
| 背景 | Research grade biosimilar. Not for use in therapeutic or diagnostic procedures for humans or animals. |
| 通用名 | ASP1650, IMAB027 |
| 货期 | In Stock |
| 产品英文名称 | Anti-CLDN6 (IMAB027) mAb |
| 内毒素 | Less than 1.0 EU/μg by the LAL method. For <1 EU/mg requirements, please contact us for customization. |
| 保质期 | 12 months from date of dispatch |
| 无菌性 | Products are supplied non-sterile. For cell culture applications, dilute in appropriate medium and sterile-filter (0.22 µm) prior to use. |
| 储存与运输 | Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature. |
| 别名 | Claudin 6;Claudin-6;Skullin |
| 应用 | ELISA; Flow Cyt |
| 有无偶联 | Unconjugated |
| 组分 | Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions of reconstitution. |
| 宿主种属 | Humanized |
| IgG亚型 | Human IgG1 - kappa |
| 反应种属 | Human |
| 推荐稀释比 | ELISA 1:5000-10000; Flow Cyt 1:100 |
| 应用范围 | Research use only |
Figure 1. Flow cytometry analysis with 1 μg/mL Anti-CLDN6 (IMAB027) mAb (BME100082) on HEK293 cells transfected with Human CLDN6 protein (Blue histogram) or HEK293 transfected with irrelevant protein (Red histogram).
Figure 2. ELISA plates were pre-coated with 0.5 μg/per well purified human CLDN6 MNPs. Serial diluted Anti-CLDN6 monoclonal antibody (BME100082) solutions were added, washed, and incubated with secondary antibody before ELISA reading. From above data, the EC50 for BME100082 binding with Claudin6 MNPs is 34.36 ng/ml.
Figure 3. Flow cytometry analysis with 15 μg/mL Anti-CLDN6 (IMAB027) mAb (BME100082) on HEK293 cells transfected with Human CLDN9 protein (Blue histogram) or HEK293 transfected with irrelevant protein (Red histogram).风险提示:丁香通仅作为第三方平台,为商家信息发布提供平台空间。用户咨询产品时请注意保护个人信息及财产安全,合理判断,谨慎选购商品,商家和用户对交易行为负责。对于医疗器械类产品,请先查证核实企业经营资质和医疗器械产品注册证情况。
文献和实验【共享】如何检测GFP、GFP、YFP、EYFP、CFP抗体?
、常规一抗以及全系列二抗,抗体检测底物以及相关试剂盒等。同时我们作为多家国际知名品牌的的中国代理或区域代理,能为您提供系列的实验室 解决方案。如果您对上述产品感兴趣,请致电027-84454412,或13317111952到***捷科技有限公司垂询相关的产品信息及完整实验解决方案。***捷科技有限公司电话:027-84454412传真:027-84454876手机:13317111952网站:www.amyjet.com地址:武汉市汉阳区龙阳大道66号新澳蓝草坪7栋1座501
STM:广州医科大学刘铭/谢茂彬合作发现肝细胞癌的新潜在治疗靶点 Claudin 6
显示,CLDN6 可以稳定 YAP1,促进其核转位,从而活化 Hippo 通路。 IP 结果显示 CLDN6 与 YAP1 竞争性结合 TJP2 鉴于 CLDN6 是多次跨膜蛋白,但其不具有(或尚未发现?)配体结合结构域,难以设计小分子药物;而如果使用单抗的话,由于肝细胞癌具有复杂的微环境, T 细胞难以发挥足够的抗体依赖细胞毒性(ADCC)效应杀伤癌细胞。因此,作者设计了靶向 CLDN6 的抗体偶联药物(Antibody-Drug Conjugate, ADC),将细胞毒性药物 DM1 和 CLDN6 抗体
GFP抗体|GFP抗体检测GFP、EGFP、YFP、EYFP、CFP抗体
区域代理,将为客户提供最具性价比的常规免疫学试剂,如各种标签 抗体、内参抗体、常规一抗以及全系列二抗,抗体检测底物以及相关试剂盒等。同时我们作为多家国际知名品牌的的中国代理或区域代理,能为您提供系列的实验室 解决方案。如果您对上述产品感兴趣,请致电027-84454412,或13317111952到 艾美捷科技 有限公司垂询相关的产品信息及完整实验解决方案。 艾美捷科技有限公司 电话: +86-027-84454412 +86-027-59846291 传真: +86
技术资料暂无技术资料 索取技术资料






