- ￥1338 - 9188
- abinScience
- 中国
- CV974013
- 2026年07月08日
- ELISA
- Canis
- Canis lupus familiaris (Dog) (Canis familiaris)
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- 文献和实验
- 技术资料
- 亚型：
IgG2, kappa
- 形态：
Liquid
- 保存条件：
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
- 克隆性：
Monoclonal
- 适应物种：
Canis lupus familiaris (Dog) (Canis familiaris)
- 保质期：
1year
- 目录编号：
CV974013
- 库存：
现货
- 供应商：
普健生物（武汉）科技有限公司
- 宿主：
Canis
- 应用范围：
ELISA
- 靶点：
B7 homolog 1
- 抗体英文名：
Anti-Canine PD-L1/B7-H1 Recombinant Antibody (12C10E4)
- 抗体名：
抗Canine PD-L1/B7-H1 重组抗体 (12C10E4)
- 规格：
50ug/100ug/1mg
| 规格： | 50ug | 产品价格： | ￥1338.0 |
|---|---|---|---|
| 规格： | 100ug | 产品价格： | ￥2288.0 |
| 规格： | 1mg | 产品价格： | ￥9188.0 |
| 产品名称 | Anti-Canine PD-L1/B7-H1 Recombinant Antibody (12C10E4) |
|---|---|
| 货号 | CV974013 |
| 宿主 | Canis |
| 种属反应性 | Canis lupus familiaris (Dog) (Canis familiaris) |
| 免疫原 | \ |
| 形态 | Liquid |
| 纯度 | >95% as determined by SDS-PAGE. |
| 克隆性 | Monoclonal |
| 亚型 | IgG2, kappa |
| 应用 | ELISA |
| 靶点 | B7 homolog 1 |
| 标记物 | \ |
abinScience, founded in 2023 in Strasbourg, France, is committed to developing and producing high-quality life science reagents. Rooted in one of Europe’s leading hubs for scientific innovation, abinScience empowers global research through reliable, efficient experimental solutions. Guided by the vision of “Empowering Bioscience Discovery,” we support scientists worldwide in advancing the frontiers of bioscience.
Technology and Innovation
Relying on the global leading position in antibody and protein research and more than 20 years of industry experience of its parent company ProteoGenix since 2003, abinScience has inherited advanced technologies and high-quality standards. In particular, the XtenCHO™ system developed by ProteoGenix, which has two modes of transient expression and stable expression, has been widely recognized as a core technology to improve the efficiency of protein production, providing a solid foundation for abinScience’s product line.
Product categories and application fields.
Main products.
10000+ high-activity proteins.
15000+ antibody series products:
Classic monoclonal antibody.
Monoclonal antibody
Internal control antibody, labeled antibody.
High-quality phosphorylation antibodies.
Highly specific nanobodies and small molecule antibodies.
Functional antibodies in vivo.
Low-background flow cytometry antibodies.
DNA/RNA antibodies and PEG antibodies.
1000+ reagent kit series products.
Large-scale packaging customization services: We offer personalized antibody design, protein production, molecular optimization, and experimental development services.
Application field
Infectious disease research: including viruses, superbugs, parasites, etc.
Neuroscience research: Supporting research on neurodegenerative diseases such as Alzheimer’s disease and Parkinson’s disease.
Immunology research: Covers the research needs of immune activation, inhibition, and allergies and abnormal reactions.
Oncology research: Supporting the development of tumor biology and anti-tumor drugs.
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文献和实验和蛋白质及肽结合。六、单一抗体片段它和轻链可变区相互作用的粘连的碎片影响了他们的溶解度和稳定性。它和抗原的亲和力较低而且和不相干的抗原有交叉反应的趋势。七、构建多价体Fv抗体为了增加单价体scFv的亲和性，可以强制缩合肽段使它们形成多聚体。八、产生式系统细菌，酵母菌，植物，昆虫细胞和哺乳动物细胞的抗体和抗体片段的产物都有它的表达系统。1、细菌不能装配所有糖基化的抗体，但是可以装配抗体片段的产物。2、酵母菌可以表达完整的抗体，但含有高的甘露糖和多分支的寡糖，而且在效应器功能方面有缺陷。3、携带杆状
了 B7 家族的第三个成员 B7-H1（即日后的 PD-L1）[2]。2000 年，Tasuku Honjo 教授等人证明了 PD-L1 能与 PD-1 结合，进而抑制 T 细胞的增殖与细胞因子的分泌，负调控淋巴细胞的激活，从此，B7-H1 被正式命名为 PD-L1（陈列平教授则继续使用「B7-H1」命名）[3]。2003年，陈列平教授第一次成功地使用 PD-L1 封闭抗体联合 T 细胞回输技术治愈了约 60% 的头颈癌小鼠[4]。2014 年 12 月，首个应用于肿瘤治疗的抗 PD-1 抗体
28、CTLA-4的局限性表达（主要在T细胞）不同，PD-1可表达于活化的T细胞、B细胞和骨髓细胞，以及CD4-CD8-胸腺细胞［1］。PD-1有两个配体，PD-L1（B7-H1）和PD-L2（B7-DC），均为B7家族中的新成员，胞外都有1个IgV样区和1个IgC样区。PD-L1含有290个氨基酸，其胞外区与B7-1、B7-2分别有20%和15%的同源性，胞浆区变化多样，但二级结构同B7-1、B7-2非常相似。在基因水平上PD-L2与PD-L1有37.4%的同源性。PD-L1和PD-L2的表达与调节不同
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