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- 技术资料
- CAS号：
2138299-34-8
- 规格：
1mLx10mM(inDMSO)/1mg/5mg/10mg/25mg/50mg/100mg
| 规格： | 1mLx10mM(inDMSO) | 产品价格： | ￥4128.0 |
|---|---|---|---|
| 规格： | 1mg | 产品价格： | ￥1136.0 |
| 规格： | 5mg | 产品价格： | ￥2304.0 |
| 规格： | 10mg | 产品价格： | ￥3912.0 |
| 规格： | 25mg | 产品价格： | ￥5976.0 |
| 规格： | 50mg | 产品价格： | ￥7896.0 |
| 规格： | 100mg | 产品价格： | ￥10800.0 |
Product Introduction
Bioactivity
| 名称 | diABZI STING agonist-1 trihydrochloride |
| 描述 | diABZI STING agonist-1 (trihydrochloride) is stimulator of interferon genes (STING) receptor agonist. |
| 动物实验 | To evaluate the potential therapeutic effects of systemically administered diABZI STING agonist-1 trihydrochloride, tested the efficacy of intravenously delivered diABZI STING in a syngeneic mouse model of colorectal tumours (CT-26) in BALB/c mice.?We first established the pharmacokinetic profile of STING in BALB/c mice following intravenous injection of 3 mg/kg .?STING exhibited systemic exposure with a half-life of 1.4 h and achieved systemic concentrations greater than the half-maximal effective concentration (EC50) for mouse STING (~200 ng/ml).?Next, we tested an intermittent dosing paradigm in which 1.5 mg/kg STING was injected intravenously on days 1, 4, and 8 in mice with approximately 100 mm^3 subcutaneous CT-26 tumours.?Treatment with STING resulted in significant tumour growth inhibition as measured by tumour volume AUC analysis (P<0.001), and significantly improved survival (P<0.001) with 8 out of 10 mice remaining tumour free at the end of the study on day 43. |
| 体外活性 | diABZI STING agonist-1 trihydrochloride 是选择性的干扰素基因刺激受体(STING)激动剂，在人和小鼠中都能发挥作用，其 EC50值分别为 130 和 186 nM。 |
| 体内活性 | 方法：diABZI STING agonist-1 (trihydrochloride) （3mg/kg，静脉注射 ）在BALB/c小鼠体内，观察小鼠体内的药代动力学谱。 结果：diABZI STING agonist-1 (trihydrochloride) 全身性暴露，半衰期为1.4 h，全身性浓度大于小鼠STING的半最大有效浓度(EC50) (200 ng /ml)。[1] 方法：diABZI STING agonist-1 (trihydrochloride) （1.5 mg/kg, 1、4和8天,静脉注射）在皮下CT-26肿瘤的小鼠中,通过肿瘤体积AUC分析。 结果：diABZI STING agonist-1 (trihydrochloride) 对肿瘤生长有明显的抑制作用，显著提高了生存率(P<0.001)。[1] |
| 存储条件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
| 溶解度 | H2O : 5 mg/mL (5.21 mM), Sonication is recommended. 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 2 mg/mL (2.08 mM), Sonication is recommended. DMSO : 15 mg/mL (15.64 mM), Sonication is recommended. |
| 关键字 | TMEM173 | STING | Stimulator of Interferon Genes | MPYS | MITA | Inhibitor | inhibit | ERIS | diABZI STING agonist-1 trihydrochloride | diABZI STING agonist1 trihydrochloride | diABZI STING agonist-1 | diABZI STING agonist 1 trihydrochloride |
| 相关产品 | SR-717 | Omaveloxolone | ChX710 | C-178 | C-176 | STING agonist-4 | Cridanimod | SN-008 | diABZI STING agonist-1 | STING ligand-1 | CCCP | 2',3'-cGAMP sodium |
| 相关库 | Immuno-Oncology Compound Library | Bioactive Compound Library | Bioactive Compounds Library Max | Anti-Pancreatic Cancer Compound Library | NO PAINS Compound Library | Immunology/Inflammation Compound Library |
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化合物 diABZI STING agonist-1 trihydrochloride【2138299-34-8】
￥1136 - 10800
