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- CAS号：
1957202-44-6
- 规格：
25mg/50mg/100mg
| 规格： | 25mg | 产品价格： | ￥8480.0 |
|---|---|---|---|
| 规格： | 50mg | 产品价格： | ￥11040.0 |
| 规格： | 100mg | 产品价格： | ￥14000.0 |
Product Introduction
Bioactivity
| 名称 | Vonoprazan hydrochloride |
| 描述 | Vonoprazan hydrochloride, a proton pump inhibitor (PPI), effectively acts as a potassium-competitive acid blocker (P-CAB) with potent antisecretory activity. It notably inhibits H+,K+-ATPase activity in porcine gastric microsomes, demonstrating an IC50 of 19 nM at pH 6.5. Primarily developed for researching acid-related diseases like gastroesophageal reflux disease and peptic ulcer disease, vonoprazan hydrochloride also serves in the eradication of Helicobacter pylori [1] [2] [3]. |
| 体外活性 | Vonoprazan (0.1 nM-10 μM; 30 minutes) exhibits porcine gastric H +, K + -ATPase activity in a concentration-dependent manner [2]. Vonoprazan does not inhibit Na +,K + -ATPase activity, even at concentrations 500 times higher than their IC 50 values against gastric H +,K + -ATPase activity [2]. |
| 体内活性 | Vonoprazan (1-4 mg/kg; p.o.) completely inhibits basal and 2-deoxy-D-glucose (200 mg/kg; s.c.)-stimulated gastric acid secretion at the 4 mg/kg dose in rats [2]. Animal Model: Male 7- or 8-week-old Sprague-Dawley rat [2] Dosage: 0.5 mg/kg, 1 mg/kg, 2 mg/kg, 4 mg/kg Administration: Oral administration Result: Inhibited basal gastric acid secretion in a dose-dependent manner. |
| 存储条件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
| 相关产品 | Adipic dihydrazide | Levulinic acid | Doxycycline | Neomycin sulfate | Terbinafine hydrochloride | BES | Dimethyl sulfoxide | Sodium bicarbonate | Hyaluronic acid sodium (MW 20 kDa) | Sodium diacetate | Sulfamethoxazole sodium | D(+)-Raffinose pentahydrate |
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化合物 Vonoprazan hydrochloride【1957202-44-6】
￥8480 - 14000
