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- 2026年07月07日
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- CAS号：
1415800-43-9
- 规格：
1mg/1mLx10mM(inDMSO)/2mg/5mg/10mg/25mg/50mg/100mg
| 规格： | 1mg | 产品价格： | ￥212.0 |
|---|---|---|---|
| 规格： | 1mLx10mM(inDMSO) | 产品价格： | ￥462.0 |
| 规格： | 2mg | 产品价格： | ￥279.0 |
| 规格： | 5mg | 产品价格： | ￥396.0 |
| 规格： | 10mg | 产品价格： | ￥662.0 |
| 规格： | 25mg | 产品价格： | ￥1408.0 |
| 规格： | 50mg | 产品价格： | ￥2520.0 |
| 规格： | 100mg | 产品价格： | ￥3616.0 |
Product Introduction
Bioactivity
| 名称 | UNC1215 |
| 描述 | UNC1215, an effective and specific MBT (malignant brain tumor) antagonist, binds L3MBTL3 (IC50/Kd: 40/120 nM). The selectivity of UNC1215 for L3MBTL3 is 50-fold higher versus other members of the human MBT family. |
| 细胞实验 | CellTiter-Glo luminescent cell viability assay(Only for Reference) |
| 激酶实验 | AlphaScreen assay: Compound plates (1 μL at 10 or 30 mM highest concentration) are diluted in 1×assay buffer (20 mM Tris pH 8.0, 25 mM NaCl, 2 mM DTT and 0.05% Tween-20) over 2 steps using a Multimek robotic pipettor and 1 μL is spotted into the wells of 384-well assay Proxiplates. To these plates 9 μL of protein- peptide mix in 1× assay buffer is added by Multidrop and incubated for 30 min at room temperature. At this point 2 μL of streptavidin-conjugate donor and nickel-chelate acceptor beads (45 μg/mL in 1× assay buffer) are added, the plates are allowed to incubate for an additional 30 min in the dark at room temperature. After incubation the plates are read on EnVision mulilabel reader equipped with HTS alpha screen laser. The screens reported are performed up to 10 or 30 μM, and therefore it should be noted that those compounds referred to as inactive are indeed inactive only within the concentration range tested. PHF23 and JARID1A are GST tagged and consequently for these assays GST-acceptor beads are used. It should be noted that any positive binding curves for L3MBTL4 that are generated yielded curves with very shallow slopes, suggesting a nonspecific interaction. The data for the IC50 values is calculated from replicate runs in that the datapoints for each compound concentration are averaged and plotted using 4-parameters curve fitting. |
| 体内活性 | UNC1215与L3MBTL3结合,竞争性置换含单或二甲基赖氨酸的肽段。UNC1215对L3MBTL3的选择性比L3MBTL1高约75倍。UNC1215无细胞毒性,通过MBT域的Kme结合口袋,直接结合到L3MBTL3。UNC1215使GFP-L3MBTL3融合蛋白的细胞移动性与点突变增加,干扰GFP-L3MBTL3表型模拟的Kme结合功能,影响UNC1215的定位。UNC1215（30 μM）不影响UHRF1的串联Tudor域、CBX7的染色质域及JARID1A的PHD域。 |
| 存储条件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
| 溶解度 | DMSO : 93 mg/mL (175.56 mM), Sonication is recommended. H2O : < 1 mg/mL (insoluble or slightly soluble) Ethanol : 93 mg/mL (175.56 mM), Sonication is recommended. 10% DMSO+40% PEG300+5% Tween-80+45% Saline : 1 mg/mL (1.89 mM), Sonication is recommended. |
| 关键字 | UNC-1215 | UNC1215 | UNC 1215 | probe | methyllysine | MBT | Malignant | L3MBTL3-D274A | L3MBTL3 | Inhibitor | inhibit | HistoneMethyltransferase | Histone Methyltransferase | EpigeneticReaderDomain | Epigenetic Reader Domain | Cerebrum | Apoptosis |
| 相关产品 | Formamide | Urea | Sodium Molybdate | Dimethyl phthalate | Aceglutamide | Alginic acid | Cysteamine hydrochloride | Metronidazole | Sildenafil citrate | Citric Acid Triammonium | Stavudine | Tamoxifen |
| 相关库 | Inhibitor Library | Bioactive Compound Library | Anti-Cancer Active Compound Library | Bioactive Compounds Library Max | Chromatin Modification Compound Library | Histone Modification Compound Library | Apoptosis Compound Library | Anti-Aging Compound Library | NO PAINS Compound Library | Epigenetics Compound Library | Membrane Protein-targeted Compound Library | Methylation Compound Library |
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相关实验
网络 第十九章 杂环化合物和生物碱 杂环化合物在自然界分布很广，其数量几乎占已知有机化合物的三分之一，用途也很多。许多重要的物质如叶绿素、血红素、核酸以及临床应用的一些有显著疗效的天然药物和合成药物等，都含有杂环化合物的结构。生物碱多是中草药的有效成分，绝大多数是含氮的杂环化合物。本章内容与医学关系密切，具有重要意义。
分子中具有高能键的化合物。在生物体内主要有上式（Ⅰ）和（Ⅱ）两种结构的高能化合物。其作用为贮藏能量（例如 ATP、肌酸磷酸）和作为产生 ATP源的中间代谢产物（例如磷酸烯醇丙酮酸）以及合成反应的中间物质（例如酰基辅酶 A），在蛋白质的结构（ conformation）变化周期的第一阶段上（例如钠钾 ATP酶的羧基磷酸中间体）也具有重要作用。多数高等化合物具有磷酸基，但也有例外。
由不同种元素组成的纯净物叫做化合物。化合物一般有固定的组成。化合物的组成一般可用化学式表示。化合物具有确定的物理性质和化学性质，不同于其组成元素的性质。化合物中的元素不能用简单的机械方法或物理方法分开，而必须用化学方法才能分离。
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化合物 UNC1215【1415800-43-9】
￥212 - 3616
