- ￥214 - 2362
- TargetMol
- T3116
- 2026年07月07日
2 年钻石会员
企业认证
相关产品推荐更多 >
万千商家帮你免费找货
0 人在求购买到急需产品
- 详细信息
- 文献和实验
- 技术资料
- CAS号：
134523-03-8
- 规格：
1mLx10mM(inDMSO)/10mg/25mg/50mg/100mg/200mg/500mg
| 规格： | 1mLx10mM(inDMSO) | 产品价格： | ￥214.0 |
|---|---|---|---|
| 规格： | 10mg | 产品价格： | ￥253.0 |
| 规格： | 25mg | 产品价格： | ￥370.0 |
| 规格： | 50mg | 产品价格： | ￥469.0 |
| 规格： | 100mg | 产品价格： | ￥702.0 |
| 规格： | 200mg | 产品价格： | ￥1104.0 |
| 规格： | 500mg | 产品价格： | ￥2362.0 |
Product Introduction
Bioactivity
| 名称 | Atorvastatin hemicalcium salt |
| 描述 | Atorvastatin hemicalcium salt (Atorvastatin Calcium) is an HMG-CoA reductase inhibitor with oral activity. Atorvastatin hemicalcium salt is used to lower cholesterol. |
| 细胞实验 | Briefly, SV-SMC from 5 different patients are seeded into 24-well cell culture plates at a density of 1×104?cells per well in full growth medium. Cells are incubated overnight and then quiesced in serum free medium for 3 days before transfer to full growth medium (10% FCS) containing 5 different statins (simvastatin, atorvastatin, fluvastatin, lovastatin, and pravastatin)at a range of concentrations. All statins are tested on cells from each individual patient. Medium and drugs are replaced after 2 days, and viable cell numbers are determined in triplicate wells after 4 days using Trypan Blue and a hemocytometer. The increase in cell number is calculated by subtracting the starting cell number (day 0) from the final cell number (day 4). Data are then normalized to control values (no statin) to correct for differences in proliferation rates between cells from different patients. |
| 体外活性 | 方法：胃癌干细胞 MKN45 用 Atorvastatin hemicalcium salt (0.39-25 µM) 处理 7 天，通过 CellTiter-Glo luminescent assay 检测细胞增殖。 结果：Atorvastatin 以 2.1 µM 的 IC50 值剂量依赖性地抑制 MKN45 细胞的增殖。[1] 方法：HUVECs 细胞用 Atorvastatin hemicalcium salt (0.7-35 µM) 处理 24 h，通过 Western Blot 检测靶点蛋白表达水平。 结果：35 µM Atorvastatin 治疗后，凋亡标志物 cleaved caspase-3 和 cleaved PARP-1 的蛋白表达水平在 HUVECs 中显著上调。[2] |
| 体内活性 | 方法：为研究对动脉粥样硬化的作用，将 Atorvastatin hemicalcium salt (10 mg/kg) 灌胃给药给易损动脉粥样硬化斑块小鼠模型，每天一次，持续八周。 结果：Atorvastatin 在该剂量下没有降低血浆总胆固醇水平或影响斑块进展。然而，与对照组相比，Atorvastatin 治疗组的易损斑块数量显著减少。Atorvastatin 可以改善小鼠的斑块稳定性，而与血浆胆固醇水平无关。[3] |
| 存储条件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
| 溶解度 | DMSO : 122.5 mg/mL (212.06 mM), Sonication is recommended. 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 4 mg/mL (6.92 mM), Sonication is recommended. |
| 关键字 | HMGCR | HMGCoAReductase | HMG-CoA reductase | HMGCoA Reductase | Ferroptosis | CI981 | CI 981 | Autophagy | Atorvastatin hemicalcium salt | Atorvastatin |
| 相关产品 | Guanidine hydrochloride | Naringin | Sodium Molybdate | Aceglutamide | Alginic acid | Cysteamine hydrochloride | Hemin | Hydroxychloroquine | Sildenafil citrate | Stavudine | Tamoxifen | Paeonol |
| 相关库 | Inhibitor Library | Anti-Cancer Approved Drug Library | Bioactive Compound Library | Bioactive Compounds Library Max | Drug-induced Liver Injury (DILI) Compound Library | Metabolism Compound Library | Anti-Aging Compound Library | FDA-Approved Drug Library | Anti-Neurodegenerative Disease Compound Library | Drug Repurposing Compound Library | Anti-Cancer Clinical Compound Library | Anti-Cancer Drug Library |
风险提示：丁香通仅作为第三方平台，为商家信息发布提供平台空间。用户咨询产品时请注意保护个人信息及财产安全，合理判断，谨慎选购商品，商家和用户对交易行为负责。对于医疗器械类产品，请先查证核实企业经营资质和医疗器械产品注册证情况。
文献和实验该产品被引用文献
官网有文献
技术资料暂无技术资料 索取技术资料
文献支持
阿托伐他汀钙【134523-03-8】
￥214 - 2362
