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- 详细信息
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- 技术资料
- CAS号：
1448189-80-7
- 规格：
50mg
Product Introduction
Bioactivity
| 名称 | (S,R,S)-AHPC hydrochloride |
| 描述 | (S,R,S)-AHPC hydrochloride (Protein degrader 1 hydrochloride) is a building block in the synthesis of proteolysis-targeting chimera technologies (PROTACs). |
| 体外活性 | 小分子诱导的蛋白质降解是开发化学探针的一种有吸引力的策略。蛋白质降解剂能够一次性废止药物靶标的所有功能，包括那些难以用小分子抑制剂靶向的框架功能。开发了一种新型的PROTACs，这些PROTACs成功整合了小分子VHL配体来降解HaloTag7融合蛋白。HaloPROTACs将激发具有更多药物样性质的未来PROTACs的发展。在稳定表达GFP-HaloTag7的HEK 293细胞中，HaloPROTAC1的24小时处理使得GFP-Halotag7的降解率不到20%，而更长的HaloPROTAC2可以使GFP-Halotag7在2.5 μM的条件下降解率接近70%。当使用足够长的连接器时，含有蛋白降解剂1的HaloPROTACs可以使GFP-HaloTag7的降解率接近70%。 |
| 存储条件 | Keep away from direct sunlight Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
| 溶解度 | DMSO : 10 mM, Sonication is recommended. 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 2 mg/mL (4.28 mM), Sonication is recommended. |
| 关键字 | VHL ligand-1 | VHL ligand1 | VHL Ligand 1 Hydrochloride | VHL ligand 1 | VH032-NH2 | ULM1 | ULM 1 | Protein degrader 1 Hydrochloride | Ligands for E3 Ligase | LigandforE3Ligase | Ligand for E3 Ligase | Inhibitor | inhibit | E3 ligase-recruiting Moiety | AHPC Hydrochloride | (S,R,S)AHPC hydrochloride | (S,R,S)-AHPC | (S,R,S) AHPC hydrochloride |
| 相关产品 | Lenalidomide | PT-179 | Pomalidomide | (S,R,S)-AHPC | (S)-Thalidomide | Lenalidomide-Br | Amino-PEG1-C2-acid | Thalidomide | Thalidomide 5-fluoride | Thalidomide-O-COOH | Thalidomide-5-OH | 5-Aminothalidomide |
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文献和实验Protocol for FastTrack 2.0 mRNA Extraction Human Cells
. Modified FastTrack 2.0 Protocol Isolation of mRNA Add 15ml of Lysis Buffer （15ml Stock Buffer 300 ul RNase/Protein Degrader） to the frozen pellet. The tissue homogenizer should be cleaned so that it is RNase-free. At a minimum will require immersion
Human FastTrack mRNA Isolation
. Modified FastTrack 2.0 Protocol Isolation of mRNA 1.Add 15ml of Lysis Buffer (15ml Stock Buffer + 300 ul RNase/Protein Degrader) to the frozen pellet. 2.The tissue homogenizer should be cleaned so that it is RNase-free. At a minimum will require
Expression Library Screening (Procaryotic) Using AP-Fusion Proteins
is titered, i.e. the number of pfu (plaque forming units) per ml is determined. Then the library is plated. After the initial formation of plaques, IPTG-soaked nitrocellulose filters are applied to stimulate the lacZ promoter and consequently the protein
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