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- CAS号：
2095432-58-7
- 规格：
1mLx10mM(inDMSO)/1mg/5mg/10mg/25mg/50mg/100mg
| 规格： | 1mLx10mM(inDMSO) | 产品价格： | ￥872.0 |
|---|---|---|---|
| 规格： | 1mg | 产品价格： | ￥397.0 |
| 规格： | 5mg | 产品价格： | ￥792.0 |
| 规格： | 10mg | 产品价格： | ￥1264.0 |
| 规格： | 25mg | 产品价格： | ￥2312.0 |
| 规格： | 50mg | 产品价格： | ￥3176.0 |
| 规格： | 100mg | 产品价格： | ￥4632.0 |
Product Introduction
Bioactivity
| 名称 | SAG hydrochloride (912545-86-9(free base)) |
| 描述 | SAG hydrochloride (912545-86-9(free base)) (Smoothened Agonist HCl) acts as an SMO agonist. |
| 动物实验 | Animal Models: RatFormulation: DMSODosages: 2.5 nMAdministration: Intracerebroventricular administration(Only for Reference) |
| 体外活性 | SAG regulates Smo activity by binding directly to the Smo heptahelical bundle. [1] SAG induces Smo-dependent signaling through Gli in a GRK2-dependent way. [2] SAG also (1 nM) induces proliferation of neuronal and glial precursors without affecting the differentiation pattern of newly produced cells. |
| 体内活性 | In the adult rat hippocampus, the intracerebroventricular administration of SAG (2.5 nM) significantly increases the number of newly generated cells and extends survival of hippocampal cells. [3] In mice, SAG (20 μg/g, i.p.) effectively prevents GC-induced neonatal cerebellar developmental abnormalities. |
| 存储条件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
| 溶解度 | Ethanol : 38 mg/mL (72.17 mM), Sonication is recommended. 10% DMSO+90% Saline : 7.5 mg/mL (14.24 mM), Solution. DMSO : 75 mg/mL (142.44 mM), Sonication is recommended. 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 2 mg/mL (3.8 mM), Sonication is recommended. |
| 关键字 | Smoothened | SAG hydrochloride (912545-86-9(free base)) | SAG hydrochloride (912545869(free base)) | SAG hydrochloride (912545 86 9(free base)) | Hedgehog/Smoothened | Hedgehog |
| 相关产品 | ALLO-2 | 5-LOX inhibitor | Halcinonide | Triparanol | Ellagic acid | MRT-83 | Naftifine hydrochloride | GANT 61 | Vismodegib | IHR-1 | RU-SKI 43 | Itraconazole |
| 相关库 | Bioactive Compound Library | Anti-Cancer Compound Library | Bioactive Compounds Library Max | Anti-Pancreatic Cancer Compound Library | Cancer Cell Differentiation Compound Library | NO PAINS Compound Library | Stem Cell Differentiation Compound Library | GPCR Compound Library | Membrane Protein-targeted Compound Library | Neuronal Differentiation Compound Library | Wnt/Hedgehog/Notch Compound Library | Reprogramming Compound Library |
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Acids Glycine 75 50 0.667 L-Alanine 89 25 0.281 L-Arginine 211 105 0.498 L-Asparagine-H2O 150 50 0.333 L-Aspartic acid 133 30 0.226 L-Cysteine hydrochloride-H2O 176 100 0.568 L-Cystine 2HCl 313 31 0.0990 L-
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化合物 SAG hydrochloride【2095432-58-7】
￥397 - 4632
