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- CAS号:
761436-81-1
- 规格:
1mLx10mM(inDMSO)/1mg/5mg/10mg/25mg/50mg/100mg
| 规格: | 1mLx10mM(inDMSO) | 产品价格: | ¥944.0 |
|---|---|---|---|
| 规格: | 1mg | 产品价格: | ¥333.0 |
| 规格: | 5mg | 产品价格: | ¥789.0 |
| 规格: | 10mg | 产品价格: | ¥1208.0 |
| 规格: | 25mg | 产品价格: | ¥1992.0 |
| 规格: | 50mg | 产品价格: | ¥2840.0 |
| 规格: | 100mg | 产品价格: | ¥3832.0 |
Product Introduction
Bioactivity
| 名称 | ALK inhibitor 1 |
| 描述 | ALK inhibitor 1 is a selective ALK kinase inhibitor. |
| 体外活性 | ALK inhibitor 1 抑制了IGF-1R的活性。 |
| 存储条件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
| 溶解度 | H2O : 0.1 mg/mL (0.18 mM) 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 3.3 mg/mL (5.87 mM), Sonication is recommended. DMSO : 90 mg/mL (160.01 mM), Sonication is recommended. |
| 关键字 | TSSK2 | testis-specific | serine/threonine | reversible | PTK2 protein tyrosine kinase 2 | PTK2 | male | kinase | Inhibitor | inhibit | IGF-1R | IGF1R | Focal adhesion kinase | focal | FAK | contraception | Cluster of differentiation 246 | CD246 | Anaplastic lymphoma kinase (ALK) | Anaplastic lymphoma kinase | ALK tyrosine kinase receptor | ALK inhibitor-1 | ALK inhibitor1 | ALK inhibitor 1 | ALK | adhesion |
| 相关产品 | Tranexamic acid | Crizotinib | Semaglutide | A 83-01 | Sorbic acid | Insulin (human) | L-Cysteine hydrochloride hydrate | Ornithine-α-ketoglutarate | Linsitinib | SB-431542 | Alectinib | Brigatinib |
| 相关库 | Inhibitor Library | Bioactive Compound Library | Anti-Cancer Active Compound Library | Anti-Cancer Compound Library | Bioactive Compounds Library Max | Kinase Inhibitor Library | Anti-Aging Compound Library | Membrane Protein-targeted Compound Library | Drug Repurposing Compound Library | Tyrosine Kinase Inhibitor Library | Anti-Cancer Clinical Compound Library | Anti-Cancer Drug Library |
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文献和实验平行路径共同实现 B. pinnatum 提取物化合物 1 (槲皮素糖苷) 的潜在靶点确定[1]。 在对接路径上,研究者通过 PDB 数据库构建了一个超过 9K 个蛋白的靶点配体数据库,使用 MarvinSketch 构建槲皮素糖苷的三维结构。为简化筛选流程,首先使用槲皮素糖苷的母核槲皮素与超过 9000 个蛋白靶点的配体数据库进行粗筛,以快速得到能足够容纳槲皮素糖苷口的潜在蛋白。随后选取粗筛 Top50 的潜在作用靶点与槲皮素糖苷进行逐一对接筛选,发现其中 TOP5 的靶点中有两个与抗炎抗氧
Generation of Novel Rat and Human Pluripotent Stem Cells by Reprogramming and Chemical Approaches
) have been generated from both mouse and human somatic cells by genetic transduction. We had successfully established novel rat iPSCs (riPSCs), which can be homogenously maintained by LIF and a cocktail of ALK5 inhibitor, GSK3 inhibitor and MEK inhibitor. riPSCs share
同源性——属于哪个家族? 一、根据磷酸化底物分类 根据其作用的底物类型,激酶主要可分为四类:蛋白激酶、脂质激酶、碳水化合物激酶和核酸激酶。其中,蛋白激酶因其成员数量最多、调控网络最复杂、与疾病发生发展的关联最为直接,成为药物研发的绝对焦点。通常所说的“激酶靶点”,绝大多数即指蛋白激酶。 表1. 根据磷酸化底物对激酶分类[1]。 二、根据序列与进化导向分类
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