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- TargetMol
- FL0195
- 2026年07月07日
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- CAS号：
102195-79-9
- 规格：
200mg
Product Introduction
Bioactivity
| 名称 | N-Boc-4-hydroxy-L-proline methyl ester |
| 描述 | N-Boc-cis-4-hydroxy-L-proline methyl ester serves as a non-cleavable linker in antibody-drug conjugate (ADC) synthesis and functions as an alkyl chain-based PROTAC linker for PROTAC construction[2]. |
| 体外活性 | ADC由抗体构成，其通过ADC连接体附着有ADC细胞毒素[1]。PROTAC包含通过连接体连接的两种不同配体；一种是E3泛素连接酶的配体，另一种是目标蛋白的配体。PROTAC利用细胞内的泛素-蛋白酶体系统，选择性地降解目标蛋白[2]。 |
| 存储条件 | Keep away from direct sunlight Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
| 关键字 | N-Boc-4-hydroxy-L-proline methyl ester | Compound FL0195 | ADCLinker | ADC Linker |
| 相关产品 | 11-Aminoundecanoic acid | Tranexamic acid | N-Hydroxysulfosuccinimide sodium | Lenalidomide-Br | Azido-PEG1 | N-(4-Carboxycyclohexylmethyl)maleimide | Boc-C16-COOH | Succinic anhydride | Triethylene glycol | Tetraethylene glycol | 1,3-Dibromo-5,5-dimethylhydantoin | m-PEG12-NHS ester |
| 相关库 | Featured Fragment Library | High Solubility 3D Diversity Fragment Library | High Solubility Micro Fragment Library | High Solubility Fragment Library | High Solubility Polyfunctional Group Fragment Library |
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文献和实验Metabolic Labeling of Prenyl and Carboxyl‐Methyl Groups
that are incorporated as prenoids??e.g., farnesyl and geranylgeranyl. Carboxy?methylation often accompanies prenylation. The methyl group can be labeled using [3 H?methyl]methionine.
to replace combinattons of leucme coupled with valine in pepttde sequences. The preparation described is the final method developed, after many early less successful attempts. The synthesis mvolves (Fig. 1 ) the coupling of 1-bromo-5-methyl-2-hexene 3 and N
Radioligand Binding Assays for the Glycine Site on N‐Methyl‐D‐Aspartate Receptors
., Mutel, V., Trube, G., Malherbe, P., Kew, J.N., Mohacsi, E., Heitz, M.P., and Kemp, J.A. 1997. Ro 25‐6981, a highly potent and selective blocker of N‐methyl‐D‐aspartate receptors containing the NR2B subunit: Characterization in vitro. J. Pharmacol. Exp
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