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- CAS号：
484-11-7
- 规格：
5g/10g
| 规格： | 5g | 产品价格： | ￥215.0 |
|---|---|---|---|
| 规格： | 10g | 产品价格： | ￥334.0 |
Product Introduction
Bioactivity
| 名称 | Neocuproine |
| 描述 | Neocuproine is a copper(I) chelator that enhances the purinergic component of vasoconstriction induced by electric field stimulation, and is often used as a ligand reagent and copper ion detector.Neocuproine forms stable complexes with copper ions and can play a catalytic role in certain chemical reactions and analytical methods.Neocuproine acts as a redox-active on the iron and cobalt ligand platform for protection against oxidative damage in NSC34 cells. |
| 体外活性 | Neocuproine (100 lM) 通常抑制炎症介质的生成。[2] Neocuproine 处理降低了 IFN-γ、MCP-1、MCP-3 和 VEGF-A 的水平。KC/GRO 的产生由于 Neocuproine 缺乏而下调。[2] 与 ATP7A 缺乏不同，Neocuproine 减少了 FGF-9、IL-1α、IL-12p70、IL-2、IL-3、IL-4、IL-6、MIP-1β、MIP-2、RANTES 和 TNFα 的产生。[2] |
| 体内活性 | Neocuproine (100微摩) 显著抑制了去卵巢非妊娠大鼠子宫自发收缩的幅度和频率，而该化合物却能在妊娠大鼠和人类子宫中促进自发或催产素诱导的收缩频率，但不改变这些收缩的幅度。Neocuproine (200微摩) 能增强妊娠子宫收缩的幅度。这些效应被嘌呤类受体拮抗剂舒拉明 (100微摩) 阻断，并且在给予neocuproine-铜(I) 复合物或铜(II) 螯合剂cuprizone后不发生。alpha, beta-甲烷基ATP增加了妊娠子宫收缩的幅度和频率，但对去卵巢非妊娠大鼠子宫的收缩无影响，而neocuproine增强了这种促进效应。 |
| 存储条件 | Keep away from direct sunlight,Keep away from moisture Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
| 溶解度 | DMSO : 70.71 mg/mL (339.53 mM), Sonication is recommended. 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 8.33 mg/mL (40 mM), Solution. 10% DMSO+90% Saline : < 7.07 mg/mL (33.95 mM), Lower concentrations may be soluble, but exact solubility limit is unknown. 10% DMSO+40% PEG300+5% Tween-80+45% Saline : 3.3 mg/mL (15.85 mM), Sonication is recommended. |
| 关键字 | Neocuproine | copper chelator |
| 相关库 | Bioactive Compound Library | Bioactive Compounds Library Max | Human Metabolite Library |
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文献和实验网络 附表11（1） 相关系数界值表 P(2): 0.50 0.20 0.10 0.05 0.02 0.01 0.005 0.002 0.001 P(1): 0.25 0.10 0.05 0.025 0.01 0.005 0.0025 0.001 0.0005 1 0.707 0.951 0.988 0.997 1.000 1.000
centrifugation in density gradients ofPercoll. Arch. Biochem. Biophys. 217, 312-323. 5. Leaver, C. J., Hack, E., and Forde, B. G. (1983) Protein synthesis by isolated plantmitochondria. Methods Enzymol. 97,476-484. 6. Day, D. A., Neuburger, M
Foundations,Raven Press,New York,1986 8.Noble D.The surprising teart, a revieq of recent progress in cardiac electrophysiology. J Physiol 1984;353:1-50 9.Reuter H.Ion channels in cardiac cell menbrane.Ann Rev Physiol 1984;46:473-484 10.Irisawa H et
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