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- TargetMol
- T2848
- 2026年07月07日
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- CAS号：
484-12-8
- 规格：
1g/1mLx10mM(inDMSO)/50mg/100mg/500mg
| 规格： | 1g | 产品价格： | ￥784.0 |
|---|---|---|---|
| 规格： | 1mLx10mM(inDMSO) | 产品价格： | ￥164.0 |
| 规格： | 50mg | 产品价格： | ￥116.0 |
| 规格： | 100mg | 产品价格： | ￥150.0 |
| 规格： | 500mg | 产品价格： | ￥438.0 |
Product Introduction
Bioactivity
| 名称 | Osthole |
| 描述 | Osthole (Osthol), a potential inhibitor of histamine H1 receptor, has been shown to stimulate osteoblast proliferation and differentiation. |
| 细胞实验 | Osthole is dissolved in 96% ethyl alcohol and then sterilized through a 0.22 μg/mL filter and stored at 4°C as stock solutions for later dilution[1]. Peripheral blood samples are collected from participants between 7.00 and 9.00 a.m. on the first study day and these are concentrated in grouping tubes with K3EDTA. Fresh PBMCs are then prepared. Isolated cells are seeded on 24-well plates at 1×106 per well with RPMI-1640 and supplemented with 1% heat inactivated human AB serum, 1% gentamicin and 0.25% PHA. Active reagents are added to each well after 24 h and pure medium formed the control for each substance. Cells are then harvested after a further three days[1]. |
| 体外活性 | Osthole在不同的动物中的LD50分别是,大鼠>125 mg/kg(i.v.);兔子>35 mg/kg(i.v.);狗>150 mg/kg(i.v.). |
| 体内活性 | 在洗涤过的兔血小板中, Osthol能够抑制ADP,花生四烯酸,PAF,胶原蛋白,离子载体A23187和凝血酶诱导的血小板聚集和ATP释放。在人成骨细胞中,Osthole通过骨形态发生蛋白-2 / p38和细胞外信号调节激酶1/2通路,介导细胞分化。在细胞培养中,Osthole通过增加HBsAg的糖基化,抑制乙型肝炎病毒的分泌。 |
| 存储条件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
| 溶解度 | Ethanol : 46 mg/mL (188.3 mM), Sonication is recommended. 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 2 mg/mL (8.19 mM), Sonication is recommended. DMSO : 55 mg/mL (225.14 mM), Sonication is recommended. H2O : < 1 mg/mL (insoluble) |
| 关键字 | Parasite | Osthole | NSC-31868 | NSC31868 | Inhibitor | inhibit | HistamineReceptor | Histamine Receptor | Hepatitis B virus | HBV | H1 receptor | Apoptosis |
| 相关产品 | 2-Amino-2-methyl-1-propanol | Formamide | Urea | Aceglutamide | Fenpyroximate | Alginic acid | Doxycycline | Metronidazole | Hydroxychloroquine | Lamivudine | Stavudine | Tamoxifen |
| 相关库 | Inhibitor Library | Bioactive Compound Library | Anti-Tumor Natural Product Library | Traditional Chinese Medicine Monomer Library | GPCR Compound Library | Anti-Parasitic Compound Library | Anti-Neurodegenerative Disease Compound Library | Membrane Protein-targeted Compound Library | Anti-virus Traditional Chinese Medicine Monomer Library | Pain-Related Compound Library | Antiparasitic Natural Product Library | Anti-infective Natural Product Library |
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文献和实验研究范围内，对蛇床子素提取率影响较为显著的是萃取压力（z1）与分离Ⅰ温度（z4）的交互作用；次为显著的是：分离Ⅱ温度(z5)、分离Ⅰ温度（z4）与分离Ⅱ温度(z5)的交互作用、萃取压力（z1）；有一定影响的是：萃取温度（z2）与分离Ⅰ温度（z4）的交互作用、萃取温度（z2）与分离Ⅰ压力（z3）的交互作用、分离Ⅰ压力（z3）与分离Ⅱ温度（z5）的交互作用。回归方程：蛇床子素的提取率（%）=3.70+0.10x1-0.042x2+0.058x3+0.12x5+0.055x1x2-0.05x1x3-0.20
12 mL of Plasmodium falciparum blood culture at 4% hematocrit Equipment Refrigerated centrifuge capable of holding 15 mL conical tubes Microcentrifuge Procedure Centrifuge parasite culture at 1400 rpm (~484xg
新冠病毒全球累计确诊已超过 484 万人，累计死亡 32 万多人。随着科技攻关工作的逐步推进，人类对新冠病毒和新冠肺炎的相关知识了解不断深入。在这场人类与新冠病毒惊心动魄的战争中，人类已经从和新冠病毒持续胶着状态进入主动进攻和主动防御阶段。 全世界的科研人员筛选了数以万计的可能用于新冠病毒治疗和预防的已知药物和疫苗，同时建立了多条研发未知有效药物和疫苗的路径，尝试治疗或预防新冠病毒。 增强巨噬细胞活性，活化 T 淋巴细胞， 增强机体细胞免疫功能的卡介
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