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- CAS号：
30636-90-9
- 规格：
1mLx10mM(inDMSO)/5mg/10mg/50mg/100mg
| 规格： | 1mLx10mM(inDMSO) | 产品价格： | ￥309.0 |
|---|---|---|---|
| 规格： | 5mg | 产品价格： | ￥304.0 |
| 规格： | 10mg | 产品价格： | ￥429.0 |
| 规格： | 50mg | 产品价格： | ￥1486.0 |
| 规格： | 100mg | 产品价格： | ￥2229.0 |
Product Introduction
Bioactivity
| 名称 | (20S)-Protopanaxadiol |
| 描述 | (20S)-Protopanaxadiol (20-Epiprotopanaxadiol) (20-Epiprotopanaxadiol), an apoptosis inducer, is an aglycon metabolic derivative of the protopanaxadiol-type ginseng saponin. |
| 细胞实验 | Int-407 and Caco-2 cells are seeded at a concentration of 1×106 cells/mL in 24-well plates in separate experiments. Test ginsenosides (PPD, PPT, Rh2) are added to wells to the LC50 concentration determined previously from the MTT assays. The ginsenoside concentrations used for Int-407 cells are 23, 26, and 53 μg/mL, respectively, for PPD, PPT, and Rh2. In a similar experiment using Caco-2 cells, 24 μg/mL for both PPD and PPT and 55 μg/mL for Rh2 is used. Untreated cells represented the control. Cells are incubated at 37℃ in a 5% CO2 humidified incubator for 24, 48, and 72 h. Cell-free supernatant are obtained by centrifugation(400 g) for 10 min, and the lactate dehydrogenase (LDH) assay is conducted as previously reported.(Only for Reference) |
| 体外活性 | (20S)-Protopanaxadiol对Int-407细胞的生长抑制50%浓度(LC50)为23μg/ml，而在Caco-2细胞中，(20S)-Protopanaxadiol的LC50确定为24μg/ml。(20S)-Protopanaxadiol在Int-407细胞系中产生大量的sub-G1（凋亡）细胞（Int-407细胞系是来自大约2个月胚胎的非恶性人类胚胎细胞系，而Caco-2是人类结肠腺癌细胞系）。这一反应归因于各个人参皂苷糖基化的差异，从而影响亲疏水平衡[2]。(20S)-Protopanaxadiol的孵育还显著降低U251-MG和U87-MG细胞的存活率，这种效果呈剂量和时间依赖性。(20S)-Protopanaxadiol的细胞毒作用伴随着细胞粘附蛋白表达的降低，包括N-钙黏着蛋白和整合素β1，进而导致焦点粘附激酶的磷酸化减少。此外，(20S)-Protopanaxadiol孵育减少了cyclin D1的表达，并随后诱导细胞周期在G1阶段停滞[3]。 |
| 体内活性 | 在应用(20S)-Protopanaxadiol和PPT处理后，可在高架十字迷宫（EPM）测试中显著增加开放臂区的逗留时间及进入次数。(20S)-Protopanaxadiol处理能有效抑制固定应激引起的皮质醇及白细胞介素(IL)-6水平，其通过酶联免疫吸附测定法（enzyme-linked immunosorbent assay）进行测定。(20S)-Protopanaxadiol和PPT可能分别通过γ-氨基丁酸A（GABAA）受体和5-羟色胺受体展现抗焦虑效果，而(20S)-Protopanaxadiol对于抗炎作用的潜力可能超过PPT[1]。 |
| 存储条件 | Keep away from moisture,Keep away from direct sunlight Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
| 溶解度 | 10% DMSO+90% Corn Oil : 3.3 mg/mL (7.16 mM), Sonication is recommended. 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 10 mg/mL (21.7 mM), Suspension. 10% DMSO+90% Saline : < 10 mg/mL (21.7 mM), Lower concentrations may be soluble, but exact solubility limit is unknown. Ethanol : 31 mg/mL (67.28 mM), Sonication is recommended. DMSO : 103.1 mg/mL (223.78 mM), Sonication is recommended. H2O : < 1 mg/mL (insoluble or slightly soluble) |
| 关键字 | various tumor cells | saponins | ReactiveOxygenSpecies | Reactive Oxygen Species | Protopanaxadiol | P-gp (P-glycoprotein) | P-gp | Pgp | P-glycoprotein | Multidrug resistance protein 1 | MDR1 | Inhibitor | inhibit | ginseng | Cluster of differentiation 243 | CD243 | Apoptosis inducer | Apoptosis | Akt activity | ABCB1 | 20APPD | (20S)-Protopanaxadiol | (20S)Protopanaxadiol | (20S) Protopanaxadiol |
| 相关产品 | Allopurinol | Formamide | Urea | Kaolin | Aceglutamide | Alginic acid | Metronidazole | Sildenafil citrate | Stavudine | Ethoxyquin | Tamoxifen | Ethyl linoleate |
| 相关库 | Bioactive Compound Library | Bioactive Compounds Library Max | Ancient Chinese Classical Formulas Compound Library | Miao medicine Compound Library | Anti-Aging Compound Library | Natural Product Library | Traditional Chinese Medicine Monomer Library | Tobacco Monomer Library | Membrane Protein-targeted Compound Library | Immunology/Inflammation Compound Library | Terpene Natural Product Library | Anti-Inflammatory Traditional Chinese Medicine Compound Library |
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文献和实验【选题投稿】还在为 Meta 选刊烦恼？20+ 本选优期刊汇总
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Purification of Large Cytosolic Proteases for In Vitro Assays: 20S and 26S Proteasomes
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