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- 2026年07月07日
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- 技术资料
- CAS号：
195514-63-7
- 规格：
1mg/2mg/5mg/10mg/25mg/50mg/100mg
| 规格： | 1mg | 产品价格： | ￥454.0 |
|---|---|---|---|
| 规格： | 2mg | 产品价格： | ￥669.0 |
| 规格： | 5mg | 产品价格： | ￥1352.0 |
| 规格： | 10mg | 产品价格： | ￥2288.0 |
| 规格： | 25mg | 产品价格： | ￥3800.0 |
| 规格： | 50mg | 产品价格： | ￥5424.0 |
| 规格： | 100mg | 产品价格： | ￥7352.0 |
Product Introduction
Bioactivity
| 名称 | Rimiducid |
| 描述 | Rimiducid is a lipid-permeable tacrolimus analogue, homodimerizing an analogue of human protein fkbp12 and binding to wild-type fkbp12 with 1000-fold lower affinity. Rimiducid is a dimerizer agent that acts by cross-linking the FKBP domains. It dimerizes the Caspase 9 suicide switch and rapidly induces apoptosis. |
| 体外活性 | AP1903, a bivalent 'dimerizer' drug that binds FKBP and induces Fas cross-linking.?A single 2-hour treatment eliminated approximately 80% of T cells, and multiple exposures induced further apoptosis.?T cells were eliminated regardless of their proliferation state, suggesting that the AP1903/Fas system, which contains only human components, is a promising alternative to HSV-tk for treating GVHD[2]. |
| 体内活性 | 持续的hGH分泌为监测活体内可存活细胞数量提供了一种便捷准确的方法，因为在小鼠中hGH的血清半衰期仅约3分钟。我们连续3天将这些细胞通过肌内(i.m.)植入裸鼠，并通过静脉(i.v.)给予不同剂量的Rimiducid处理这些动物，然后测定血清hGH水平以评估存活细胞的数量。Rimiducid (AP1903; i.v.,0.01, 0.1, 1, 10, 和 100 mg/kg)引发的血清人类GH水平降低呈剂量依赖性，半最大有效剂量为0.4±0.1 mg/kg[1]。 |
| 存储条件 | Powder: -20°C for 3 years Shipping with blue ice/Shipping at ambient temperature. |
| 溶解度 | 10% DMSO+90% Saline : < 10 mg/mL (7.08 mM), Lower concentrations may be soluble, but exact solubility limit is unknown. 10% DMSO+40% PEG300+5% Tween 80+45% Saline : < 10 mg/mL (7.08 mM), Lower concentrations may be soluble, but exact solubility limit is unknown. DMSO : 135 mg/mL (95.63 mM), Sonication is recommended. 10% DMSO+90% Corn Oil : 2.5 mg/mL (1.77 mM), Sonication is recommended. 10% DMSO+90% Corn oil : 10 mg/mL (7.08 mM), Solution. 10% DMSO+90% (20% SBE-β-CD in Saline) : < 10 mg/mL (7.08 mM), Lower concentrations may be soluble, but exact solubility limit is unknown. |
| 关键字 | Rimiducid | Inhibitor | inhibit | FKBP | FK506-binding protein | FattyAcidSynthase | Fatty Acid Synthase | Fas receptor | Fas | Apoptosis | AP-1903 | AP1903 | AP 1903 |
| 相关产品 | Formamide | Urea | Sodium Molybdate | Dimethyl phthalate | Aceglutamide | Alginic acid | Cysteamine hydrochloride | Metronidazole | Sildenafil citrate | Citric Acid Triammonium | Stavudine | Tamoxifen |
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文献和实验buffer 到65℃ ；(b)称取大豆粉0.1g ,放入2ml Eppendorf 管；(c)加入400μl AP1 buffer 和4μl RNase (100mg/ml )，混匀，注重避免皮肤接触AP1 buffer ，65℃孵育10-15min ；(d)加入130μl AP2buffer ,混匀，置于冰上5min ,(在酸性溶液中蛋白质和多聚糖可发生沉淀)，冰浴，沉淀未折叠的蛋白质，或使其他蛋白质发生错误折叠，并灭活DNA 酶。溶液AP2含乙酸，应避免皮肤接触； (e)12000×g将混合
Blocking of unwanted non-specific staining
that may affect your staining. Blocking of endogenous Alkaline Phosphatase is done by exploiting the differential sensitivity of calf intestinal AP, used as a reporter, and leukocyte AP. This latter is inhibited, while the former is not by Levamisole 1 mM
JNK 信号转导通路研究发现，用紫外线照射细胞后，一种蛋白激酶能够磷酸化f―jun，其磷酸化位点位于c―jun氨基末端活性区Set63和Ser73，该蛋白激酶被称为c―jun氨基末端激酶(c―jun N―terminal kinase，JNK)。JNK原来被称为应激激活的蛋白激酶(SAPK)。与其他MAPK一样，当酪氨酸和苏氨酸残基发生磷酸化后，JNK／SAPK也可被激活。JNK可以受各种各样的细胞外刺激而激活，这些刺激包括生长因子、细胞因子和细胞应激。细胞应激又包括热休克、脂多糖、肿瘤
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