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- 文献和实验
- 技术资料
- CAS号：
22161-81-5
- 规格：
1mLx10mM(inDMSO)/100mg
| 规格： | 1mLx10mM(inDMSO) | 产品价格： | ￥95.0 |
|---|---|---|---|
| 规格： | 100mg | 产品价格： | ￥95.0 |
Product Introduction
Bioactivity
| 名称 | S-(+)-Ketoprofen |
| 描述 | S-(+)-Ketoprofen ((S)-(+)-Ketoprofen) works by blocking the action of a substance in the body called cyclo-oxygenase. It belongs to a class of medicines called non-steroidal anti-inflammatory drugs (NSAIDs). Cyclo-oxygenase is involved in the production of chemicals in the body called prostaglandins. Prostaglandins are produced in response to injury or certain diseases and would otherwise go on to cause swelling, inflammation and pain. By blocking cyclo-oxygenase, S-(+)-Ketoprofen prevents the production of prostaglandins and therefore reduces inflammation and pain. Along with Peripheral analgesic action it possesses central analgesic action.S-(+)-Ketoprofen is a non-steroidal anti-inflammatory drug. It is manufactured by Menarini, under the tradename Keral. It is available in the UK, as S-(+)-Ketoprofen trometamol, as a prescription-only drug and in Latin America as Miracox, produced by Stein in Costa Rica. In Italy it is available as an over the counter-drug under the tradename Enantyum. In Lithuania it is available as over the counter-drug uder tradename Dolmen. |
| 存储条件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
| 溶解度 | 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 4 mg/mL (15.73 mM), Sonication is recommended. DMSO : 125 mg/mL (491.58 mM), Sonication is recommended. |
| 关键字 | S-Ketoprofen | S(+)Ketoprofen | S (+) Ketoprofen | RP19583 | RP 19583 | Ketoprofen | Inhibitor | inhibit | Cyclooxygenase | COX-2 | COX-1 | COX |
| 相关产品 | Trometamol | Gallic Acid Monohydrate | Naproxen sodium | 4-Aminosalicylic acid | 5-Methylfurfural | Phenylbutazone | Indomethacin | Paradol | Acetaminophen | Diclofenac Potassium | Magnesium sulfate | Phenidone |
| 相关库 | Inhibitor Library | Bioactive Compound Library | Anti-Cancer Approved Drug Library | Bioactive Compounds Library Max | Anti-Aging Compound Library | FDA-Approved Drug Library | Immunology/Inflammation Compound Library | Pain-Related Compound Library | Drug Repurposing Compound Library | Anti-Cancer Clinical Compound Library | Anti-Cancer Drug Library | Anti-Prostate Cancer Compound Library |
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相关实验
，a = 1.01。随着DDG 的增加，对映体选择性将表现为相应的指数级增长。Pirkle等用实验印证了这种关系[8]，在图2所示的CSP上，用30% 异丙醇/正己烷为流动相，N-(3， 5-二硝基苯甲酰基)-亮氨酸正己酰胺的对映异构体选择性测定值a = 10.5，其中(S)-对映体保留较长，相互作用能之差DDG = -5.93 kJ/mol。 同样，对具有两个手性中心如图3所示化合物的(SS)， (RR)对映体，可以预料：由于手性中心相隔较远，与CSP作用的自由能之差为2DD Gm ，实验
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(S)-(+)-酮洛芬【22161-81-5】
￥95
