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- 详细信息
- 文献和实验
- 技术资料
- 形态:
Liquid
- 保存条件:
4°C
- 克隆性:
单克隆
- 标记物:
APC
- 适应物种:
Human
- 保质期:
12 months
- 级别:
一抗
- 供应商:
武汉研升生物科技有限公司
- 宿主:
Mouse
- 应用范围:
FCM
- 抗体英文名:
Anti-Human CD112R/PVRIG Antibody (CPA.7.021), APC
- 规格:
50T/100T
| 规格: | 50T | 产品价格: | ¥1740.0 |
|---|---|---|---|
| 规格: | 100T | 产品价格: | ¥2892.0 |
| Product name | Anti-Human CD112R/PVRIG Antibody (CPA.7.021), APC |
| Catalog No. | HP700137 |
| Target | C7orf15, CD112R, CD112 receptor receptor-related immunoglobulin domain-containing protein, PVRIG, Transmembrane protein PVRIG |
| Clone ID | CPA.7.021 |
| Accession | Q6DKI7 |
| Clonality | Monoclonal |
| Isotype | IgG1, kappa |
| Host species | Mouse |
| Species reactivity | Human |
| Applications | FCM |
| Conjugation | APC |
| Form | Liquid |
| Storage buffer | 0.01M PBS, pH 7.4, 0.2% BSA, 0.05% Proclin 300. |
| Stability and Storage | Store at 4°C for 12 months. Protect from light. Do not freeze. |
| Note | For flow cytometric staining, the suggested use of this reagent is 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application. For research use only. |

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文献和实验三句话读懂一篇 CNS:Nature 报道治疗心肌梗死的靶点;燃烧卡路里的开关是这个基因...
). https://doi.org/10.1038/s41467-021-23265-y2. Guo, Y., Xie, YQ., Gao, M. et al. Metabolic reprogramming of terminally exhausted CD8+ T cells by IL-10 enhances anti-tumor immunity. Nat Immunol 22, 746–756 (2021). https://doi.org/10.1038/s41590-021-00940-23
不只是 PD-1:CD96 正成为免疫治疗的下一个“必争之地”
,CD96 主要与 CD155 结合,而 CD112R(PVRIG)主要与 CD112 结合 [1]。这些抑制性受体与共刺激受体 CD226 竞争相同配体,尤其是 CD155 和 CD112 [1],[10]。因此,受体之间的竞争和协同,共同决定了 T 细胞和 NK 细胞的最终功能状态。 3.3 CD96 下游信号通路:MEK-ERK 通路如何传导信号 CD96 与配体结合后可引发胞内信号转导,这是其发挥生物学作用的关键。研究表明,在 CD8+ T 细胞中,CD96 可发挥共刺激功能。当在人或小鼠
Cell Surface Immunofluorescence Staining Protocol
-CD4-Biotin, and anti-CD8-APC) and incubate on ice for 15-20 minutes in the dark. 9) Wash 2X with at least 2 ml of Cell Staining Buffer by centrifugation at 350 x g for 5 minutes. 1) If using a purified primary antibody, resuspend
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