CD36 Polyclonal antibody

【产品概述】
本产品为CD36 Polyclonal antibody（货号：18836-1-AP），由Rabbit / IgG宿主制备。该抗体属于Polyclonal抗体，可识别human来源的靶蛋白，经测试适用于WB, IHC, ELISA等实验应用。产品形式为Liquid，偶联物类型为Unconjugated。

【背景介绍】
Function CD36, also known as platelet glycoprotein 4, is an integral membrane glycoprotein that acts as a scavenger receptor. CD36 can bind to multiple ligands, including thrombospondin-1, collagen, oxidized phospholipids, oxidized low-density lipoprotein, and long-chain fatty acids. CD36 can also bind to erythrocytes parasitized by Plasmodium falciparum and apoptotic cells. CD36 mediates different biological processes, acting as a signaling hub in angiogenesis, inflammatory response, and fatty acid metabolism. Tissue specificity CD36 is present on the surface of various cells types, such as adipocytes, monocytes, macrophages, platelets, microvascular endothelial cells, dendritic cells, and hematopoietic precursors of red cells. Involvement in disease Mutations in CD36 can give rise to platelet glycoprotein IV deficiency, a type of macrothrombocytopenia. Polymorphisms in CD36 can increase susceptibility to malaria. AAGIC haplotype at the CD36 locus increases the risk of coronary heart disease. Disruption of CD36-dependent pathways and certain SNPs in the CD36 gene are attributed to impaired fatty acid metabolism, glucose intolerance, Alzheimer's disease, atherosclerosis, arterial hypertension, diabetes, and cardiomyopathy. Isoforms Apart from the full-length protein (isoform 1), one additional shorter isoform has been reported (PMID: 7509795). Other alternative isoforms have also been detected on the mRNA level (PMID: 17673938). Post-translational modifications The extracellular domain of CD36 is extensively glycosylated. Glycosylation is needed for the transport of CD36 to the plasma membrane, as well as mediating recognition and binding to ligands. Cytoplasmic tails of transmembrane domains can be phosphorylated and play a role in signal transduction. Intracellular domains can be additionally acetylated, ubiquitinated, and palmitoylated (PMID: 28919632). Cellular localization CD36 is present on the cell surface.

【产品特点】
本抗体采用Antigen affinity purification方式纯化，确保了高特异性和批次间一致性。观测分子量约为88 kDa。推荐稀释比：WB: WB : 1:500-1:2000；IHC: IHC : 1:400-1:1000。Western Blot检测阳性对照组织/细胞为Human peripheral blood platelets。储存缓冲液为PBS with 0.02% sodium azide and 50% glycerol, pH 7.3.，储存条件为Store at -20°C. Stable for one year after shipment.Aliquoting is unnecessary for -20oC storage.。Proteintech抗体经过严格的质量验证流程，确保研究人员获得可重复且可靠的实验结果。

【产品信息】
GenBank蛋白编号：BC008406；基因名称：CD36；Gene ID (NCBI)：948；UNIPROT ID：P16671；RRID：AB_10597244；别名包括：Glycoprotein IIIb, GP3B, GP4, GPIIIB, GPIV；免疫原为Peptide种属同源性预测；储存缓冲液为PBS with 0.02% sodium azide and 50% glycerol, pH 7.3.，储存条件为Store at -20°C. Stable for one year after shipment.Aliquoting is unnecessary for -20oC storage.；产品形式为Liquid；纯化方式为Antigen affinity purification。