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重组蛋白 IL-21 Human

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  • ¥600 - 16800
  • 上海经科
  • 中国
  • JK7694
  • 2026年05月21日
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    • 详细信息
    • 文献和实验
    • 技术资料
    • 保存条件

      -20℃

    • 保质期

      3 months at -20°C

    • 英文名

      IL-21, Human

    • 库存

      现货

    • 供应商

      上海经科化学科技有限公司

    • 规格

      10μg/50μg/1mg

    规格:10μg产品价格:¥600.0
    规格:50μg产品价格:¥2200.0
    规格:1mg产品价格:¥16800.0
    产品简介
    Species Human
    Protein Construction

    Expressed with an N-terminal Met.

    IL-21 (Gln30-Ser162)
    Accession # Q9HBE4
    Purity > 95% as analyzed by SDS-PAGE
    Endotoxin Level < 0.2 EU/μg of protein by gel clotting method
    Biological Activity ED50≤ 3.0 ng/ml, measured by its ability to enhance IFN-gamma secretion in NK-92 human natural killer lymphoma cells.
    Expression System E. coli
    Apparent Molecular Weight ~15.4 kDa, on SDS-PAGE under reducing conditions.
    Formulation Lyophilized after extensive dialysis against PBS.
    Reconstitution It is recommended that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute the lyophilized powder in ddH₂O up to 100 μg/ml.
    Storage & Stability Upon receiving, this product remains stable for 6 months at lower than -70°C. Upon reconstitution, the product should be stable for 1 week at 4°C or for 3 months at -20°C. For long term storage it is recommended that a carrier protein (example 0.1% BSA) be added. Avoid repeated freeze-thaw cycles.
    技术背景
    Target Background Interleukin-21 (IL-21) belongs to the Type I four helix bundle cytokines, and shares the common cytokine receptor γ chain with IL-2, IL-4, IL-7, IL-9, and IL-15. IL-21 is expressed by CD4+ T cells, natural killer (NK) T cells, and Th17 cells, and the IL-21 receptor is highly expressed on CD4+ and CD8+ B cells; indeed, IL-21 plays a pivotal role in the survival and proliferation of B cells, and their differentiation to immunoglobulin (Ig) producing cells. IL-21 up-regulates and down-regulates the production of IgG1 and IgE by B cells, respectively, and diminishes the severity of allergy and asthma. In some case, IL-21 also induces the apoptosis of B cells. The other roles of IL-21 include regulation of innate immune systems, implication on autoimmunity, and antitumor actions.
    Synonyms IL21; CVID11; IL-21; Za11; interleukin 21

    产品特点:

    1. 【人源天然序列】采用人源 HRG1-1 天然氨基酸序列,无突变,与体内天然蛋白结构完全一致,可特异性结合 HRG1-1 配体2. 【高活性高特异性】可特异性结合 HRG1-1 抗体,ED₅₀ < 100 ng/mL(抗体结合实验),可被 HRG1-1 特异性抗体识别,适用于抗体筛选、抗原检测3. 【高纯度低内毒素】SDS-PAGE 纯度 > 95%,内毒素 < 0.2 EU/μg(LAL 法),适配细胞培养、体内动物实验等敏感场景需求4. 【易纯化检测】哺乳动物细胞表达,可通过亲和层析快速纯化,也可通过 HRG1-1 特异性抗体进行检测5. 【稳定易保存】蛋白储存液配方优化,未开封 - 80℃可稳定保存 12 个月,-20℃可存 6 个月,避免反复冻融可长期保持蛋白活性6. 【多场景适配】可用于 HRG1-1 蛋白结构与功能研究、细胞培养添加剂、抗体制备与筛选、药物靶点验证等

    HRG1-1, 人源,人,重组蛋白,重组,高活性,高纯度,低内毒素,细胞培养,科研实验,哺乳动物细胞表达,Human,HRG1-1,Recombinant protein,High activity,High purity,Low endotoxin,Cell culture,Mammalian expression

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    图标文献和实验
    该产品被引用文献
    Interleukin-21 (IL-21) belongs to the Type I four helix bundle cytokines, and shares the common cytokine receptor γ chain with IL-2, IL-4, IL-7, IL-9, and IL-15. IL-21 is expressed by CD4+ T cells, natural killer (NK) T cells, and Th17 cells, and the IL-21 receptor is highly expressed on CD4+ and CD8+ B cells; indeed, IL-21 plays a pivotal role in the survival and proliferation of B cells, and their differentiation to immunoglobulin (Ig) producing cells. IL-21 up-regulates and down-regulates the production of IgG1 and IgE by B cells, respectively, and diminishes the severity of allergy and asthma. In some case, IL-21 also induces the apoptosis of B cells. The other roles of IL-21 include regulation of innate immune systems, implication on autoimmunity, and antitumor actions.
    相关实验
    • Human IL-2 Enzyme Immunoassay (EIA)

      Increased division and maturation of activated helper T cells Stimulation of neutrophils Stimulus for the secretion of interferon-( and tumor necrosis factors - aphla and - Beta from peripheral mononuclear cells. The Endogen Human IL-

    • Evaluation of IL-2-Withdrawal-Induced Apoptosis in Human T Lymphocytes

      pathway of lymphocyte apoptosis triggered by starvation for IL-2 or other survival cytokines.

    • 细胞因子和重组蛋白溶解必读(一)

      我们知道,PeproTech的所有细胞因子和蛋白均为冻干粉,这使得运输非常便捷,只要常温即可。而且,细胞因子和蛋白冻干粉非常稳定,在-20℃或-80℃条件下可保存数年。冻干粉在使用前需进行溶解,然后以液体形式加到培养体系或注射入动物体内。溶解步骤非常关键,因溶解不好会导致细胞因子或蛋白的失活,这也是很多用户在实际使用中经常遇到的问题。 那么,应该如何进行正确的溶解呢? 下面我们以Recombinant Human IL-4 (重组人IL-4,产品编号:200-04)的说明书为例

    图标技术资料

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    重组蛋白 IL-21 Human
    ¥600 - 16800