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重组蛋白 FGF-acidic 小鼠

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  • ¥300 - 5000
  • 上海经科
  • 中国
  • JK7692
  • 2026年05月21日
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    • 详细信息
    • 文献和实验
    • 技术资料
    • 保存条件

      -20℃

    • 保质期

      3 months at -20°C

    • 英文名

      FGF-acidic, Mouse

    • 库存

      现货

    • 供应商

      上海经科化学科技有限公司

    • 规格

      10μg/50μg/1mg

    规格:10μg产品价格:¥300.0
    规格:50μg产品价格:¥600.0
    规格:1mg产品价格:¥5000.0
    产品简介
    Species Mouse
    Protein Construction
    FGF-acidic (Phe16-Asp155)
    Accession # P61148
    Purity > 95% as analyzed by SDS-PAGE
    > 95% as analyzed by HPLC
    Endotoxin Level < 0.2 EU/μg of protein by gel clotting method
    Biological Activity ED50 < 0.4 ng/ml, measured by a cell proliferation assay using 3T3 cells in the presence of 10.0 µg/ml heparin, corresponding to a specific activity of > 2.5 × 106 U/mg.
    Expression System E. coli
    Apparent Molecular Weight ~15.8 kDa, on SDS-PAGE under reducing conditions.
    Formulation Lyophilized after extensive dialysis against PBS.
    Reconstitution It is recommended that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute the lyophilized powder in ddH₂O up to 100 μg/ml.
    Storage & Stability Upon receiving, this product remains stable for 6 months at lower than -70°C. Upon reconstitution, the product should be stable for 1 week at 4°C or for 3 months at -20°C. For long term storage it is recommended that a carrier protein (example 0.1% BSA) be added. Avoid repeated freeze-thaw cycles.
    技术背景
    Target Background Fibroblast Growth Factor- acidic (FGF-acidic) is a mitogen targeting at the endothelial cells, and belongs to the heparin binding FGF family, which contains 22 members. FGF-acidic binds to the receptor family FGFR1-4 in vivo with the assistance of heparin. However, along with FGF -basic, FGF-acidic lacks the signal peptide segment, and thus is not secreted via endoplasmic reticulum (ER) and Golgi bodies. Studies have shown that FGF-acidic is highly regulated, and it is a direct angiogenesis factor. If unregulated, angiogenesis could contribute to several diseases including arthritis, diabetes, ocular neovascularization, and especially tumors. Therefore, FGF-acidic is treated as a potential oncogene, and its overexpression is correlated tightly with several cancers.
    Synonyms Fibroblast Growth Factor-acidic; HBGF-1; ECGF-beta; FIBP; FGFIBP; FIBP-1; ECGF; ECGFA; GLIO703; FGF1; FGF-a

    产品特点:

    1. 【人源天然序列】采用人源 NGF-R 天然氨基酸序列,无突变,与体内天然蛋白结构完全一致,可特异性结合 NGF 配体2. 【高活性高特异性】可高效结合 NGF 配体,ED₅₀ < 100 ng/mL(配体结合实验),可被 NGF-R 特异性抗体识别,适用于抗体筛选、神经发育机制研究3. 【高纯度低内毒素】SDS-PAGE 纯度 > 95%,内毒素 < 0.2 EU/μg(LAL 法),适配细胞培养、体内神经发育实验等敏感场景需求4. 【易纯化检测】哺乳动物细胞表达,可通过亲和层析快速纯化,也可通过 NGF-R 特异性抗体进行检测5. 【稳定易保存】蛋白储存液配方优化,未开封 - 80℃可稳定保存 12 个月,-20℃可存 6 个月,避免反复冻融可长期保持蛋白活性6. 【多场景适配】可用于 NGF-R 蛋白结构与功能研究、神经发育与再生机制研究、细胞培养添加剂、药物筛选、抗体研发等

    NGF-R, 神经生长因子受体,人源,人,重组蛋白,重组,高活性,高纯度,低内毒素,细胞培养,科研实验,哺乳动物细胞表达,Human,NGF-R,Recombinant protein,Nerve growth factor receptor,High activity,High purity,Low endotoxin,Cell culture,Mammalian expression

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    图标文献和实验
    该产品被引用文献
    Fibroblast Growth Factor- acidic (FGF-acidic) is a mitogen targeting at the endothelial cells, and belongs to the heparin binding FGF family, which contains 22 members. FGF-acidic binds to the receptor family FGFR1-4 in vivo with the assistance of heparin. However, along with FGF -basic, FGF-acidic lacks the signal peptide segment, and thus is not secreted via endoplasmic reticulum (ER) and Golgi bodies. Studies have shown that FGF-acidic is highly regulated, and it is a direct angiogenesis factor. If unregulated, angiogenesis could contribute to several diseases including arthritis, diabetes, ocular neovascularization, and especially tumors. Therefore, FGF-acidic is treated as a potential oncogene, and its overexpression is correlated tightly with several cancers.
    相关实验
    • Nature|Fgf17 如何逆转大脑衰老?

      最敏感,他们还进一步确定了 Fgf17 是在衰老的大脑中恢复少突胶质细胞功能的关键靶点。 图片来源:Nature 二、主要研究内容 (一)幼龄小鼠脑脊液对少突胶质细胞的调控 首先,该团队试图测试向老年小鼠注入年轻的脑脊液是否能改善海马与衰老相关的损伤,如学习和记忆。他们对 20 个月大的老鼠进行了足部电击,然后小鼠被随机分为两组,分别注入人工脑脊液(aCSF)或幼鼠脑脊液(YM-CSF),在 3 周后进行记忆测试。结果发现,注射 YM-CSF 的小鼠对恐惧记忆保存得更好。 由于海马

    • 小鼠碱性成纤维生长因子(FGF-2)ELISA试剂盒 说明书

        上海西唐生物科技有限公司   021-55229872,  65333639   www.westang.com 小鼠碱性成纤维生长因子 ( FGF - 2 )ELISA 试剂盒   ( 用于血清、血浆、细胞培养上清液和其它生物体液内 )   原理 本实验采用双抗体夹心  ABC-ELISA 法。用抗小鼠   FGF-basic   单抗包被于酶标板上,标准品和样品中的   FGF-basic

    • 成功逆转衰老!来自年轻身体的多种物质,可让衰老小鼠「重返青春」

      in aged mice via Fgf17,该研究发现将年轻小鼠的脑脊液直接注入衰老的大脑可以明显改善记忆功能,其中少突胶质细胞对这种恢复最敏感,同时进一步确定了 Fgf17 是在衰老的大脑中恢复少突胶质细胞功能的关键靶点,助力衰老大脑「重返青春」[5]。 图片来源:Nature 人体内还有一种物质,也跟衰老紧密相关,那就是肠道菌群。 一篇在 Nature Aging 杂志发表的文章发现,将年轻小鼠的肠道菌群移植给老年小鼠,能够明显抵消小鼠大脑中与衰老相关的特定改变,进而表明了粪便移植对衰老

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    文献支持
    重组蛋白 FGF-acidic 小鼠
    ¥300 - 5000