- ￥119 - 3087
- AmBeed
- A386994
- 2026年05月29日
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- 文献和实验
- 技术资料
- 英文名：
4-(Di(1H-indol-3-yl)methyl)phenol
- 供应商：
上海安毕达生物科技有限公司
- CAS号：
151358-47-3
- 规格：
50μL/1mL/1mg/5mg/10mg/25mg/50mg/100mg
| 规格： | 50μL | 产品价格： | ￥119.0 |
|---|---|---|---|
| 规格： | 1mL | 产品价格： | ￥578.0 |
| 规格： | 1mg | 产品价格： | ￥273.0 |
| 规格： | 5mg | 产品价格： | ￥472.0 |
| 规格： | 10mg | 产品价格： | ￥598.0 |
| 规格： | 25mg | 产品价格： | ￥1197.0 |
| 规格： | 50mg | 产品价格： | ￥1827.0 |
| 规格： | 100mg | 产品价格： | ￥3087.0 |
The orphan nuclear receptor NR4A1 (nuclear receptor 4A1) exhibits pro-oncogenic activity in cancer cell lines. NR4A1 activates mTOR signaling, regulates genes such as thioredoxin domain containing 5 and isocitrate dehydrogenase 1 that maintain low oxidative stress, and coactivates specificity protein 1 (Sp1)-regulated pro-survival and growth promoting genes. DIM-C-pPhOH binds NR4A1 and act as antagonists. DIM-C-pPhOH (20 μM; 18 hr) inhibited growth and induced apoptosis in ACHN and 786-O cells, and the functional and genomic effects of it were comparable to those observed after NR4A1 knockdown. Moreover, treatment of these cells with 0–20 μM of the NR4A1 antagonist DIM-C-pPhOH also significantly decreased cell proliferation. IC50 values for DIM-C-pPhOH were 13.6 μM and 13.0 μM in ACHN cells and 786-O cells, respectively. Moreover, treatment of athymic nude mice bearing ACHN cells as xenografts with DIM-C-pPhOH (30 mg/kg/d) for 50 days also resulted in a significant inhibition of tumor growth and complemented results of the in vitro studies. In addition, researchers also observed decreased expression of survivin, bcl-2, EGFR and induced PARP cleavage in tumor lysates from nude mice bearing ACHN cells as a xenograft and treated with DIM-C-pPhOH (30 mg/kg/d)1.
溶解方案(细胞实验)
DMSO 中的溶解度 : 125 mg/mL (369.39 mM; 超声助溶 (<60°C); 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)
溶解方案(动物实验)
"方案 一": "请依序添加每种溶剂：10% DMSO 40% PEG300 5% Tween-80 45% SalineSolubility: ≥ 2.08 mg/mL (6.15 mM); 澄清溶液 此方案可获得 ≥ 2.08 mg/mL（饱和度未知）的澄清溶液。以 1 mL 工作液为例，取 100 μL 20.8 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；再向上述体系中加入 50 μL Tween-80，混合均匀；然后再继续加入 450 μL 生理盐水 定容至 1 mL。生理盐水的配制：将 0.9 g 氯化钠，溶解于 ddH₂O 并定容至 100 mL，可以得到澄清透明的生理盐水溶液。"
"方案 二": "请依序添加每种溶剂：10% DMSO 90% (20% SBE-β-CD in Saline)Solubility: ≥ 2.08 mg/mL (6.15 mM); 澄清溶液 此方案可获得 ≥ 2.08 mg/mL（饱和度未知）的澄清溶液。以 1 mL 工作液为例，取 100 μL 20.8 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液 中，混合均匀。2 g SBE-β-CD（磺丁基醚 β-环糊精）粉末定容于 10 mL 的生理盐水中，完全溶解至澄清透明。"
"方案 三": "请依序添加每种溶剂：10% DMSO 90% Corn OilSolubility: ≥ 2.08 mg/mL (6.15 mM); 澄清溶液 此方案可获得 ≥ 2.08 mg/mL（饱和度未知）的澄清溶液，此方案实验周期在半个月以上的动物实验酌情使用。以 1 mL 工作液为例，取 100 μL 20.8 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。"
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文献和实验【原创】轻松反转基因序列，UT转换，互补配对。自己编写的小软件，简单实用。发放源代码！！！
的几个引物设计软件就是用VB编写的。我自己编写的这个软件十分简单，界面如下： 代码呈上： Private Sub Command1_Click() Dim j As Integer, c As String c = Text3.Text c = Replace(c, "A", "Q") c = Replace(c, "T", "A") c = Replace(c, "Q", "T") c = Replace(c, "C", "W") c
Preparation of Segmented and Polarity Marked Microtubules
1. Polymerize bright GMPCPP seed mix at 37¡C for 15'-30'. 2. On ice prepare the dim elongation mix consisting of 15 µM tubulin (1 part rhodamine tubulin to 10 parts unlabeled tubulin ) in 1X BRB80, 1 mM DTT, 1 mM GTP. Incubate at 0¡C for 5' and (optionally
Preparation of Segmented and Polarity Marked Microtubules
nitrogen and storing at -80¡C. II. Segmented Taxol Microtubules 1. Polymerize bright GMPCPP seed mix at 37¡C for 15'-30'. 2. On ice prepare the dim elongation mix consisting of 15 µM tubulin (1 part rhodamine tubulin
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