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- 详细信息
- 文献和实验
- 技术资料
- 供应商:
武汉研升生物科有限公司
- 检测范围:
0.16-10 ng/mL
- 检测方法:
Sandwich
- 适应物种:
Human
- 样本:
tissue homogenates, cell lysates and other biological fluids
- 灵敏度:
0.053 ng/mL
- 规格:
48T/96T
| 规格: | 48T | 产品价格: | ¥1680.0 |
|---|---|---|---|
| 规格: | 96T | 产品价格: | ¥2400.0 |
| 中文名称 | 人过氧化物酶体增殖物激活受体γ辅激活因子1α(PPARgC1a)酶联免疫吸附检测试剂盒 |
| 英文名称 | Human PPARgC1a(Peroxisome Proliferator Activated Receptor Gamma Coactivator 1 Alpha) ELISA Kit |
| 别名 | LEM6; PGC-1(alpha); PGC-1v; PGC1; PGC1A; PPARGC1; Ligand effect modulator 6 |
| 货号 | ELK3099 |
| 反应种属 | Human |
| Q9UBK2 | Q9UBK2 |
| 检测类型 | Sandwich |
| 灵敏度 | 0.053 ng/mL |
| 标准品 | 10 ng/mL |
| 检测范围 | 0.16-10 ng/mL |
| 样本类型 | tissue homogenates, cell lysates and other biological fluids |
| 反应时间 | 3.5h |
| 检测原理 | The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human PPARgC1a. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human PPARgC1a. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added, only those wells that contain Human PPARgC1a, biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Human PPARgC1a in the samples is then determined by comparing the OD of the samples to the standard curve. |
| 研究领域 | CD & Adhesion molecule; |

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文献和实验crinology. First published April 3, 2003 as doi:10.1210/ me. 2002- 0410 Title:Peroxisome Proliferator-activated Receptor γ Inhibits Expression of Minichromosome Maintenance Proteins in Vascular Smooth Muscle Cells 过氧化物酶体增殖子激活受体γ(PPARγ)抑制血管平滑肌细胞内微型染色体维系蛋白
。 最近发现本类药物是过氧化物酶增殖激活受体α(peroxisome proliferator activated receptor-alpha, PPAR-α)的激动剂。PPAR-α是细胞内、外脂代谢的主要调节者,激活后通过抑制Apo C Ⅲ转录,增加脂蛋白脂肪酶(LPL)及载脂蛋白Apo AI的生成,使血浆TG水平显著降低,HDL-C 水平增高。此外,实验研究表明,benafibrate也有抑制肝脏HMG-CoA还原酶的作用,抑制胆固醇的合成,并经反馈调节机制使LDL受体数目增加,促进
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