- ￥1200 - 2150
- EnkiLife
- APRab12372
- 2026年04月17日
- WB,ELISA
- Rabbit
- Human,Rat,Mouse
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- 文献和实验
- 技术资料
- 形态：
Liquid
- 保存条件：
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
- 标记物：
Unconjugated
- 适应物种：
Human,Rat,Mouse
- 供应商：
武汉恩玑生命科技有限公司
- 宿主：
Rabbit
- 应用范围：
WB,ELISA
- 规格：
50uL/100uL
| 规格： | 50uL | 产品价格： | ￥1200.0 |
|---|---|---|---|
| 规格： | 100uL | 产品价格： | ￥2150.0 |
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研究背景
This gene encodes a member of the HIN-200 (hematopoietic interferon-inducible nuclear antigens with 200 amino acid repeats) family of cytokines. The encoded protein contains domains involved in DNA binding, transcriptional regulation, and protein-protein interactions. The protein localizes to the nucleoplasm and nucleoli, and interacts with p53 and retinoblastoma-1. It modulates p53 function, and inhibits cell growth in the Ras/Raf signaling pathway. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2011],function:May function as a transcriptional repressor. Could have a role in the regulation of hematopoeitic differentiation through activation of unknown target genes. Controls cellular proliferation by modulating the functions of cell cycle regulatory factors including p53/TP53 and the retinoblastoma protein. May be involved in the senescence of prostate epithelial cells.,induction:Strongly induced by gamma interferon and, to a lesser extent, by alpha interferon. In HL-60 cells, maximum induction by gamma-interferon occurs within 12 hours whereas, for alpha-interferon, only 10-fold induction was observed after 36 hours. Induced in vitro by dimethylsulfoxide, retinoic acid and 1,25 dihydroxyvitamin D3.,PTM:Isoform 3 seems to show a minor degree of complex carbohydrate addition.,PTM:Phosphorylated on Ser and Thr.,sequence caution:Intron retention.,similarity:Belongs to the HIN-200 family.,similarity:Contains 1 DAPIN domain.,similarity:Contains 2 HIN-200 domains.,subunit:Isoform 1, isoform 2 and isoform 3 can homo- and hetero-dimerize. Binds double-stranded DNA and cell cycle regulatory factors including p53 and the retinoblastoma protein.,tissue specificity:Expressed in peripheral blood leukocytes, fibroblasts and lymphoid cells. Present in myeloid precursors (CD34+) and throughout monocyte development, but its expression is down-regulated in erythroid and polymorphonuclear precursor cells. Present in prostate, ovary and breast (at protein level).,
研究领域
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文献和实验Polyclonal Antibody Production
Zealand White Rabbits and have them delivered to the ARC. Don’t put all your eggs in one basket only using one rabbit. Let them get accustomed to there home there for two weeks before the first pre-bleed. Pre-bleed
Polyclonal Antibody Production
Polyclonal Antibody Production Very useful for rapid and simple generation of antibodies for western blots, ELISA assays, and immunoprecipitation. Rabbit Immunization Initial Preparation Your antigen
Generation and Selection of Rabbit Antibody Libraries by Phage Display
The rabbit antibody repertoire is an exceptional source for both polyclonal antibodies (pAbs) and monoclonal antibodies (mAbs) that combine high specificity with high avidity and affinity, respectively. In contrast to rabbit pAbs
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