BRTC1 (N-Term), (AA 17-52) 抗体

BRTC1 (N-Term), (AA 17-52) 抗体抗原
BRTC1
抗原表位
N-Term, AA 17-52
适用
人
宿主
兔
克隆类型 (克隆位点)
多克隆 (RB16275)
应用范围
Western Blotting (WB), 免疫组织化学（IHC）, 免疫萤光（IF）
Pubmed 2个引用可参考
规格 400 μL
发货至 中国 (更改)
发货时间 9至13个工作日
产品编号 yb655814
产品细节 BRTC1 (N-Term), (AA 17-52) 抗体
免疫原 This BTRC antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 17-52 AA from the N-terminal region of human BTRC.
克隆位点 RB16275
亚型 Ig
特异性 This BTRC antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 24-60 amino acids from the N-terminal region of human BTRC.
预测反应 Mouse (Murine)
纯化方法 This antibody is purified through a protein A column, followed by peptide affinity purification.
目标详细情况 BRTC1 (N-Term), (AA 17-52) 抗体
背景 This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbws class, in addition to an F-box, this protein contains multiple WD-40 repeats. This protein is homologous to Xenopus bTrCP1, yeast Met30, Neurospora Scon2 and Drosophila Slimb proteins. It interacts with HIV-1 Vpu and connects CD4 to the proteolytic machinery. It also associates specifically with phosphorylated IkappaBalpha and beta-catenin destruction motifs, probably functioning in multiple transcriptional programs by activating the NF-kappaB pathway and inhibiting the beta-catenin pathway.
Synonyms: F-box/WD repeat-containing protein 1A,BTRC,BTRCP, FBW1A, FBXW1A
分子量 68867 DA
基因ID 8945
NCBI登录号 NP_378663
UniProt Q9Y297
研究领域 Cell Signaling, Cell Structure
使用细节 BRTC1 (N-Term), (AA 17-52) 抗体
应用备注 WB = 1:1000, IHC = 1:10-50, IF = 1:10-50
限制 仅限研究用
贮存及处理 BRTC1 (N-Term), (AA 17-52) 抗体
状态 Liquid
浓度 0.28 mg/mL
缓冲液 PBS with 0.09 % (W/V) sodium azide
储存液 Sodium azide
注意事项 This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
储存条件 4 °C/-20 °C
储存方法 Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
有效期 6 months