- ￥1650 - 4230
- Leading Biology
- AMR11473N
- 美国
- 2026年03月31日
- Rabbit
- Human, Mouse
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- 详细信息
- 文献和实验
- 技术资料
- 靶点：
ELA2; GE; HLE; HNE; NE; PMN-E; SCN1
- 浓度：
Affinity purification
- 宿主：
Rabbit
- 适应物种：
Human, Mouse
- 保质期：
1-2年
- 供应商：
安诺伦（北京）生物科技有限公司
- 保存条件：
Store at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
- 形态：
形式：Liquid 储存溶液：Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
- 亚型：
IgG
- 免疫原：
A synthesized peptide derived from human Neutrophil Elastase (ELANE)
- 规格：
50 µl/100 µl/200 µl
| 规格： | 50 µl | 产品价格： | ￥1650.0 |
|---|---|---|---|
| 规格： | 100 µl | 产品价格： | ￥2685.0 |
| 规格： | 200 µl | 产品价格： | ￥4230.0 |
Observed MW: 30KDa
稀释方法：WB 1:500 - 1:2000
IHC 1:50 - 1:200
IF 1:50 - 1:200
总结：Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode structurally similar proteins. The encoded preproprotein is proteolytically processed to generate the active protease. Following activation, this protease hydrolyzes proteins within specialized neutrophil lysosomes, called azurophil granules, as well as proteins of the extracellular matrix. The enzyme may play a role in degenerative and inflammatory diseases through proteolysis of collagen-IV and elastin. This protein also degrades the outer membrane protein A (OmpA) of E. coli as well as the virulence factors of such bacteria as Shigella, Salmonella and Yersinia. Mutations in this gene are associated with cyclic neutropenia and severe congenital neutropenia (SCN). This gene is present in a gene cluster on chromosome 19. [provided by RefSeq, Jan 2016]
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文献和实验Neutrophil elastase, proteinase 3, and cathepsin G are three hematopoietic serine proteases, large quantities of which are stored in neutrophil cytoplasmic azurophilic granules. They act in combination with reactive oxygen species to degrade
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''Yan-Hua Lin''et al.(2008) Salvianolic acid B protects human endothelial cells from oxidative stress damage: a possible protective role of glucose-regulated protein 78 induction.Cardiovasc Res'' 81:148-158 10.N u Matsuda''Y Takano''S
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