- $495
- Leading Biology
- United States
- AMM08504G
- 2026年03月31日
- mouse
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- 详细信息
- 文献和实验
- 技术资料
- 亚型：
IgG2b Kappa
- 保存条件：
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
- 克隆性：
单克隆
- 库存：
100
- 宿主：
mouse
- 靶点：
WASL (NP_003932, 97 a.a. ~ 184 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
- 规格：
100 μg
54827 Da
细胞定位：
形式：
Clear, colorless solution in phosphate buffered saline, pH 7.2 .
参考文献：
Regulation of actin polymerization and adhesion-dependent cell edge protrusion by the Abl-related gene (Arg) tyrosine kinase and N-WASp. Miller MM, et al. Biochemistry, 2010 Mar 16. PMID 20146487.The rate of N-WASP exchange limits the extent of ARP2/3-complex-dependent actin-based motility. Weisswange I, et al. Nature, 2009 Mar 5. PMID 19262673.The Toca-1-N-WASP complex links filopodial formation to endocytosis. Bu W, et al. J Biol Chem, 2009 Apr 24. PMID 19213734.Overexpression of N-WASP in the brain of human epilepsy. Xiao F, et al. Brain Res, 2008 Oct 3. PMID 18708039.Inhibition of cytokinesis by wiskostatin does not rely on N-WASP/Arp2/3 complex pathway. Bompard G, et al. BMC Cell Biol, 2008 Jul 30. PMID 18667055.
产品概述：
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality WASL antibody (monoclonal) (M04).
功能：
总结：
The Wiskott-Aldrich syndrome (WAS) family of proteins share similar domain structure, and are involved in transduction of signals from receptors on the cell surface to the actin cytoskeleton. The presence of a number of different motifs suggests that they are regulated by a number of different stimuli, and interact with multiple proteins. Recent studies have demonstrated that these proteins, directly or indirectly, associate with the small GTPase, Cdc42, known to regulate formation of actin filaments, and the cytoskeletal organizing complex, Arp2/3. The WASL gene product is a homolog of WAS protein, however, unlike the latter, it is ubiquitously expressed and shows highest expression in neural tissues. It has been shown to bind Cdc42 directly, and induce formation of long actin microspikes.
联系方式：
生物商城：http://www.annoron.com
办公电话：010-56256916
官方售后：400-965-8633
企业 QQ：3212874516、3198592576
地 址：北京经济技术开发区永昌中路4号院4号楼3层
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