Phospho-Ser62,67 Synapsin I A

分子量：
78 KDa
细胞定位：

形式：
Prepared from rabbit serum by affinity purification viasequential chromatography on phospho- and dephosphopeptide affinity columns.
参考文献：
Jovanovic JN, Benfenati, F, Siow YL, Sihra TS, Sanghera JS, Pelech SL, Greengard P,Czernik AJ (1996) Neurotrophins stimulate phosphoryl ation of Synapsin I by MAP kinase and regulate Synapsin I-actin interactions. Neurobiology 93:3679-3683. Czernik AJ, Pang DT, Greengard P (1987) Amino acid sequences surrounding the cAMP-dependent and calcium/calmodulin-dependent phosphorylation sites in rat and bovine synapsin I. Proc Natl Acad Sci (USA) 84:7518-7522. Feng J, Chi P, Blanpied TA, Xu YM, Magarinos AM, Fe rreira A, Takahashi RH, Kao HT, McEwen BS, Ryan TA, Augustine GJ, Greengard P (2002) Regulation of neurotransmitter release by synapsin III. J Neurosci 22:4372- 4380. Jovanovic JN, Sihra TS, Nairn AC, Hemmings HC, Jr., Gr eengard P, Czernik AJ (2001) Opposing changes in phosphorylation of specific sites in synapsin I during Ca 2+ -dependent glutamate release in isolated nerve terminals. J Neurosci 21:7944-7953. Kao HT, Song HJ, Porton B, Ming GL, Hoh J, Abraham M, Czernik AJ, Pieribone VA, Poo MM, Greengard P (2002) A protein kinase A-dependent molecular switch in synapsin s regulates neurite outgrowth. Nature Neurosci 5:431- 437. Nayak AS, Moore CI, Browning MD (1996) CAM kinase II phos phorylation of the presyn aptic protein synapsin is persistently increased during expression of long-term po tentiation. Proc Natl Acad Sci (USA) 93:15451-15456. Melanie K. Tallent, Neal Varghis, Yuliya Skorobogatko, Lisa Hernandez-Cuebas, Kelly Whelan, David J. Vocadlo, and Keith Vosseller (2009) In Vivo Modulation of O -GlcNAc Levels Regulates Hippocampal Synaptic Plasticity through Interplay with Phosphorylation . J. Biol. Chem., Jan 2009; 284: 174 – 181 Sergio Leal-Ortiz, Clarissa L. Waites, Ryan Terry-Lorenzo , Pedro Zamorano, Eckart D. Gundelfinger, and Craig C. Garner (2008) Piccolo modulation of Synapsin1a dynamics regulates synaptic vesicle exocytosis . J. Cell Biol., 181: 831 - 846.
产品概述：
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality Phospho-Ser62,67 Synapsin I antibody.
功能：

总结：
Synapsin I plays a key role in synaptic plasticity in brain (Feng et al.,2002; Nayak et al., 1996). This effect is due in large part to the ability of the synapsins to regulatethe availability of synaptic vesicles for release. The role of synapsin in synaptic plasticity and insynaptogensis is regulated by phosphorylation (Jovanovic et al., 2001; Kao et al., 2002). Ser 549along with Ser 62 and Ser 67 are the sites of Synapsin I that are phosphorylated by MAP kinase(Czernik et al., 1987; Jovanovic et al., 1996).
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