Phospho-YAP1 (Ser127) Polyclo
nal Antibody（多克隆抗体） | Phospho-YAP1 (Ser127) Antibody | Phospho-YAP1 (Ser127)抗体- ￥2454
- CUSABIO
- 武汉
- CSB-PA593016
- 2026年03月28日
- ELISA, WB
- Rabbit
- Human, Mouse, Rat
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
Peptide sequence around phosphorylation site of serine127(A-H-S(p)-S-P) derived from Human YAP .
- 亚型：
IgG
- 形态：
liquid
- 保存条件：
-20°C or -80°C
- 克隆性：
多克隆
- 标记物：
Non-conjugated
- 适应物种：
Human, Mouse, Rat
- 抗原来源：
12个月
- 目录编号：
Homo sapiens (Human)
- 供应商：
武汉研升生物科技有限公司
- 宿主：
Rabbit
- 应用范围：
ELISA, WB
- 靶点：
YAP1
- 抗体英文名：
Phospho-YAP1 (Ser127) Antibody
- 抗体名：
Phospho-YAP1 (Ser127) Antibody
- 规格：
100μl
|
Product Name |
Phospho-YAP1 (Ser127) Antibody |
|
Code |
CSB-PA593016 |
|
Aliases |
65 kDa Yes associated protein antibody; 65 kDa Yes-associated protein antibody; COB1 antibody; YAp 1 antibody; YAP 65 antibody; YAP antibody; YAP-1 antibody; YAP1 antibody; YAP1_HUMAN antibody; YAP2 antibody; YAP65 antibody; yes -associated protein delta antibody; Yes associated protein 1 65kDa antibody; Yes associated protein 1 antibody; Yes associated protein 2 antibody; yes associated protein beta antibody; YKI antibody; Yorkie homolog antibody |
|
Product Type |
Polyclonal Antibody |
|
Immunogen Species |
Homo sapiens (Human) |
|
Size |
100μl |
|
Uniprot ID |
P46937 |
|
Immunogen |
Peptide sequence around phosphorylation site of serine127(A-H-S(p)-S-P) derived from Human YAP . |
|
Host Species |
Rabbit |
|
Species Reactivity |
Human, Mouse, Rat |
|
Tested Applications |
ELISA, WB:1:500-1:1000 |
|
Clonality |
Polyclonal |
|
Isotype |
IgG |
|
Conjugate |
Non-conjugated |
|
Buffer |
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
|
Form |
Liquid |
|
Stroage |
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. |
|
Purification Method |
Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi |
|
Target Names |
YAP1 |
|
Research Areas |
Epigenetics and Nuclear Signaling;Cancer;Signal transduction |
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文献和实验Using Phospho‐Motif Antibodies to Determine Kinase Substrates
comprising both the phosphorylated residue and the surrounding residues that determine kinase specificity, with degenerate residues taking up the remaining positions. Currently, several categories of phospho?motif antibody are commercially available
STM：广州医科大学刘铭/谢茂彬合作发现肝细胞癌的新潜在治疗靶点 Claudin 6
菲尼处理会上调 CLDN6 及相关谱系标志物的表达量，但下调增殖标志物 Ki67，表明上调 CLDN6 可能是肝癌细胞的一种应激策略，使自身进入低增殖速率的耐药状态。在分子水平上，CLDN6 可以上调 Hippo 通路转录因子 YAP1 和 TAZ 的表达量，并下调 YAP1 S127 和 S397 位点的抑制性磷酸化水平，从而活化 Hippo 通路。作者发现 CLDN6 可以与 YAP1 竞争性结合 TJP2，后者作为紧密连接复合体中的胞质支架蛋白，可以结合 YAP1 并诱导其降解。数据
kinase is KIR 3.1 and have developed a phospho-selective antibody against the Y12 motif of this channel. Much like KOR and p38 MAP kinase, phosphorylation of this potassium channel increases following repeated stress. The following chapter discusses
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