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文献和实验Analysis of Isoform Expression from Splicing Array Using Multiple Comparisons
There is a high prevalence of alternatively spliced genes (isoforms) in the human genome. Studies toward understanding aberrantly spliced genes and their association with diseases have lead researchers to profile the expression
9.18 Nature 子刊:IL- 17 激活 NOTCH 信号通路,参与细胞增殖
感受低温的功能,并在小鼠的背根神经节(DRG)得到实验证明。该工作发现谷氨酸受体蛋白 GLR- 3 /Gluk2 能够感受低于 18 摄氏度的低温,是目前科学界发现的首个低温冷受体,并且其感受低温的功能不受其离子通道功能的影响,是偶联下游 G 蛋白来行使其冷信号传递功能。原文检索:A Cold-Sensing Receptor Encoded by a Glutamate Receptor Gene ② Nature 子刊:IL- 17 激活 NOTCH 信号通路,参与细胞增殖近年来的研究发现,Th17
【进展|热点】Immunity:重要免疫因子IL-17C的受体及信号传导分子机制
C, was induced in a Th17 cell-dependent autoimmune disease and was required for its pathogenesis. IL-17C bound to IL-17RE, a member of IL-17 receptor family whose full-length isoform was selectively expressed in Th17 cells and signaled via an IL-17RA-RE receptor
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