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文献和实验Investigation of Astrocyte Oligodendrocyte Interactions in Human Cultures
Multiple sclerosis (MS) is characterized by CNS demyelination and oligodendrocyte depletion, axonal loss, and reactive astrogliosis. Myelin loss causes conduction block, while remyelination is associated with recovery
Derivation of Oligodendrocyte Progenitor Cells from Human Embryonic Stem Cells
The directed differentiation of human pluripotent stem cells into specific, determined, and high-purity cell types can provide a means to study the cellular and molecular mechanisms of development and to generate cells for potential
Transplantation of Oligodendrocyte Progenitor Cells in Animal Models of Leukodystrophies
as a curative therapy. Animal models of leukodystrophies have been valuable in developing effective strategies of myelin repair in human diseases. This chapter discusses the animal models of leukodystrophies and describes methods for (a) derivation of mouse
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