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文献和实验Evaluating Dietary Compounds in Pancreatic Cancer Modeling Systems
With the establishment of outstanding rodent models of pancreatic neoplasia and cancer, there are now systems available for evaluating the role diet, dietary supplements, and/or therapeutic compounds (which can be delivered in the diet) play
stimulation. In addition, application of cell based assays simultaneously permits entry level evaluation of compound toxicity and endows with a powerful approach to perform high-throughput screenings of, e.g., small molecule libraries in a quest for novel
为了逃避免疫攻击,癌细胞又出新招!Cancer Cell 发现连胶原蛋白也「叛变」了……
binds to a3b1 integrin and affects tumor microbiome and immunity to promote pancreatic cancer 的研究性论文,发现胰腺癌细胞产生的 I 型胶原(Col1)蛋白是一种异常的同源三聚体变体,具有致癌特性。癌细胞中 Col1 同源三聚体的缺失可抑制肿瘤进展并重塑肿瘤微生物组,增强 T 细胞浸润,使抗 PD-1 免疫治疗更有效。 图片来源:Cancer Cell 研究内容 胰腺癌细胞中存在特异性胶原
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