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文献和实验development field. Herein we provide detailed methods for the h epatocyte i maging a ssay t echnology (HIAT) and the b ile flux i maging a ssay t echnology (BIAT) to evaluate drug-induced liver injury (DILI) potentials for drug candidates. Optimized culturing
Evaluation of Mitochondrial Respiration in Cultured Rat Hepatocytes
hepatocytes can detect drugs involved in drug-induced liver injuries (DILI). The method consists in measuring oxygen consumption by using a Clark electrode in a chamber containing a suspension of hepatocytes pre-incubated with drug.
Measuring Altered Disposition of Xenobiotics in Experimental Models of Liver Disease
the metabolic pathway and excretion mechanisms governing the disposition of a compound is essential to the safe use of pharmaceutical agents. Because the liver is the primary organ responsible for the metabolism and elimination of xenobiotics, chronic liver
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