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- MCE
- HY-L075
- 2026年03月25日
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- 详细信息
- 文献和实验
- 技术资料
- 库存：
【化合物数量】2523
- 供应商：
广州市左克生物
肺癌是癌症中发病率和死亡率最高的一种癌症，是威胁人类健康的一类主要疾病。肺癌主要分为两种：小细胞肺癌和非小细胞肺癌（NSCLC），其中非小细胞肺癌是主要的肺癌类型，约占肺癌发病率的85%。 与所有癌症一样，肺癌可以通过手术、化疗、放射治疗、靶向治疗、免疫治疗或多种治疗方法结合治疗。靶向治疗是肺癌尤其非小细胞肺癌治疗中的重要进展。非小细胞肺癌通常具有广泛的基因特性，可以分为不同的分子亚型，这些亚型存在癌基因依赖性，并且对靶向治疗非常敏感。这些亚型包括表皮生长因子（EGFR）或 BRAF 突变型，EML4 与 ALK 基因融合导致 ALK 的异常表达型及 ROS1 基因与其他基因融合导致 ROS1 异常表达型等。这些都是靶向治疗中的重要靶点。 MCE 提供 [0] 个具有明确或潜在抗肺癌活性的化合物，这些化合物靶向肺癌治疗中的关键靶点及信号通路。MCE 抗肺癌化合物库是筛选抗肺癌活性化合物及其他肺癌相关研究的重要工具。
活性描述 & 特点
Biological Activity
• A unique collection of 2,667 compounds with identified and potential anti-lung cancer activity for high throughput screening (HTS) and high content screening (HCS).
• Targets include EGFR, BRAF, ROS1,ALK,etc.
• A useful tool for the discovery of anti-lung cancer drugs.
• Bioactivity and safety confirmed by preclinical research and clinical trials. Some have been approved by FDA.
• Structurally diverse, medicinally active, and cell permeable.
• Detailed compound information with structure, IC50, and brief introduction.
• Validated NMR and HPLC to ensure high purity and quality.
• All compounds are in stock and continuously updated.
产品详情
Product Details
Formulation:
A collection of 2,667 anti-lung cancer compounds supplied as pre-dissolved Solutions or Solid
Solution: 2,587 compounds supplied in 10 mM solution, 79 compounds supplied in 2 mM solution, 1 compounds supplied in 3 mg/mL solution.
Layout:
96-well storage tube or 96-well plate: 1st and 12th column are left empty.
384-well plate: the first two columns and the last two columns are left empty.
Compounds with different concentrations or dissolved in different solvents will be put on separate plates. This way of layout may increase the number of plates because there could be three solvents and three concentrations.
If you have other requirements, please let us know.
Container:
96- or 384-well Plate with Peelable Foil Seal; 96-well Format Sample Storage Tube With Screw Cap and Optional 2D Barcode
Storage:
-80°C
Shipping:
Blue ice or dry ice
化合物库组成
Composition
Apoptosis(655)
Nucleoside Antimetabolite/Analog(324)
Autophagy(292)
p38 MAPK(292)
Akt(256)
PI3K(253)
EGFR(247)
STAT(216)
VEGFR(199)
JAK(185)
Microtubule/Tubulin(171)
NF-κB(164)
mTOR(153)
Topoisomerase(137)
Reactive Oxygen Species (ROS)(124)
DNA/RNA Synthesis(116)
ERK(108)
Bacterial(104)
FGFR(99)
Endogenous Metabolite(92)
Interleukin Related(90)
c-Met/HGFR(83)
Caspase(76)
JNK(75)
Antibiotic(68)
PDGFR(65)
PD-1/PD-L1(61)
CDK(58)
Parasite(49)
Bcl-2 Family(47)
COX(47)
Ras(47)
AMPK(45)
DNA Alkylator/Crosslinker(45)
NO Synthase(45)
TNF Receptor(44)
FLT3(43)
Src(42)
ADC Payload(34)
c-Kit(34)
MMP(34)
RET(33)
Ferroptosis(30)
Fungal(30)
Keap1-Nrf2(28)
MDM-2/p53(28)
PARP(27)
HIV(24)
PERK(24)
Anaplastic lymphoma kinase (ALK)(23)
GSK-3(23)
PKC(23)
HDAC(22)
Toll-like Receptor (TLR)(22)
Raf(21)
Phosphatase(19)
HSP(18)
HSV(18)
MEK(18)
Mitophagy(18)
PPAR(18)
PROTACs(18)
Bcr-Abl(17)
Influenza Virus(17)
TGF-beta/Smad(17)
Aurora Kinase(16)
DNA-PK(16)
HIF/HIF Prolyl-Hydroxylase(16)
NOD-like Receptor (NLR)(16)
TAM Receptor(16)
Drug Metabolite(15)
Epigenetic Reader Domain(15)
Mitochondrial Metabolism(15)
Wnt(15)
Calcium Channel(14)
FAK(14)
Orthopoxvirus(14)
Ribosomal S6 Kinase (RSK)(14)
Cytochrome P450(13)
Kinesin(13)
ROS Kinase(13)
SOD(13)
β-catenin(13)
Casein Kinase(12)
TGF-β Receptor(12)
Drug Derivative(11)
Histamine Receptor(11)
IKK(11)
PKA(11)
SARS-CoV(11)
Amyloid-β(10)
Btk(10)
c-Fms(10)
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