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- MCE
- HY-L064
- 2026年03月25日
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- 库存：
【化合物数量】1407
- 供应商：
广州市左克生物
谷氨酰胺是细胞内一种重要的代谢燃料，可以满足快速增值细胞对 ATP，生物合成前体及还原剂的需求。谷氨酰胺代谢通路开始于谷氨酰胺被谷氨酰胺酶脱氨产生谷氨酸和氨。谷氨酸在谷氨酸脱氢酶（GDH）或由丙氨酸、天冬氨酸转氨酶（TAs）的作用下转化为三羧酸循环的中间产物α-酮戊二酸（α-KG），产生ATP和碳源可以用于合成氨基酸、核苷酸和脂质。在缺氧或线粒体功能缺陷时，α-酮戊二酸在异柠檬酸脱氢酶2（IDH2）催化的还原羧化反应中转化为柠檬酸，新形成的柠檬酸存在于线粒体中，用于合成脂肪酸和氨基酸，并产生还原剂 NADPH 。 代谢通路改变在肿瘤细胞中是一种常见的现象。研究表明，谷氨酰胺代谢改变对生物大分子合成，信号通路调节及维持氧化还原稳态方面发挥重要作用，而这些进程有助于维持肿瘤细胞的增殖和存活。因此，对谷氨酰胺代谢通路的研究有助于新型抗肿瘤药物的开发。 MCE 谷氨酰胺代谢库收录了 [0] 个靶向谷氨酰胺代谢通路中主要蛋白和酶的小分子化合物。是研究谷氨酰胺代谢进程的有用工具。
活性描述 & 特点
Biological Activity
• A unique collection of 1,522 glutamine metabolism -related small molecules for high throughput screening (HTS) and high content screening (HCS).
• Targets such as glucose transporter, glutamate dehydrogenase , glutaminase, c-Myc ,etc.
• A useful tool for glutamine metabolism research and anti-cancer drug discovery.
• Bioactivity and safety confirmed by preclinical research and clinical trials. Some inhibitors have been approved by FDA.
• Structurally diverse, medicinally active, and cell permeable.
• More detailed compound information with structure, IC50, and brief introduction.
• NMR and HPLC validated to ensure high purity and quality.
• All compounds are in stock and continuously updated.
产品详情
Product Details
Formulation:
A collection of 1,522 glutamine metabolism compounds supplied as pre-dissolved Solutions or Solid
Solution: 1,481 compounds supplied in 10 mM solution, 39 compounds supplied in 2 mM solution, 2 compounds supplied in 3 mg/mL solution.
Layout:
96-well storage tube or 96-well plate: 1st and 12th column are left empty.
384-well plate: the first two columns and the last two columns are left empty.
Compounds with different concentrations or dissolved in different solvents will be put on separate plates. This way of layout may increase the number of plates because there could be three solvents and three concentrations.
If you have other requirements, please let us know.
Container:
96- or 384-well Plate with Peelable Foil Seal; 96-well Format Sample Storage Tube With Screw Cap and Optional 2D Barcode
Storage:
-80°C
Shipping:
Blue ice or dry ice
化合物库组成
Composition
Apoptosis(424)
Akt(337)
ERK(257)
Autophagy(172)
Mitochondrial Metabolism(166)
MDM-2/p53(148)
Ras(141)
Reactive Oxygen Species (ROS)(136)
NF-κB(135)
HIF/HIF Prolyl-Hydroxylase(129)
PI3K(124)
p38 MAPK(114)
Sirtuin(107)
mTOR(104)
Endogenous Metabolite(84)
Caspase(78)
Bacterial(69)
Raf(67)
Interleukin Related(62)
JNK(62)
c-Myc(56)
STAT(50)
COX(45)
MEK(41)
AMPK(39)
Ribosomal S6 Kinase (RSK)(39)
Aldehyde Dehydrogenase (ALDH)(36)
NO Synthase(35)
Bcl-2 Family(32)
Ferroptosis(31)
CDK(30)
E1/E2/E3 Enzyme(30)
GLUT(30)
Keap1-Nrf2(30)
EGFR(29)
MMP(29)
Parasite(29)
PPAR(29)
TNF Receptor(29)
Fungal(28)
NADPH Oxidase(26)
PARP(26)
Glutaminase(25)
GSK-3(24)
VEGFR(24)
Isocitrate Dehydrogenase (IDH)(23)
Calcium Channel(19)
Antibiotic(18)
TGF-beta/Smad(18)
DNA/RNA Synthesis(17)
JAK(17)
Oxidative Phosphorylation(17)
PERK(17)
Phosphatase(16)
Microtubule/Tubulin(14)
PKC(14)
Influenza Virus(13)
Toll-like Receptor (TLR)(13)
Wnt(13)
Potassium Channel(12)
PROTACs(12)
SOD(12)
HSP(11)
PDGFR(11)
Src(11)
Casein Kinase(10)
FAK(10)
ROS Kinase(10)
β-catenin(10)
Adrenergic Receptor(9)
ASCT(9)
c-Met/HGFR(9)
FLT3(9)
IKK(9)
NOD-like Receptor (NLR)(9)
PKA(9)
Survivin(9)
TRP Channel(9)
Amyloid-β(8)
Cytochrome P450(8)
Drug Metabolite(8)
Epigenetic Reader Domain(8)
ROCK(8)
SARS-CoV(8)
Tyrosinase(8)
Anaplastic lymphoma kinase (ALK)(7)
Angiotensin-converting Enzyme (ACE)(7)
AP-1(7)
Estrogen Receptor/ERR(7)
Heme Oxygenase (HO)(7)
HIV(7)
Ligands for E3 Ligase(7)
Mitophagy(7)
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文献和实验Compound library HCVcc (stock titer ≥3.25 × 104 ; see protocol 3 and 2) FRET lysis buffer (see recipe ), prechilled to 4°
Uptake and Release of Amino Acid Neurotransmitters
into cerebrospinal fluid (CSF). As in most other cells, amino acids in the brain have their roles as constituents of protein, metabolic precursors, and intermediates in energy and nitrogen metabolism; furthermore these compounds are involved
Evaluation of Rett Syndrome Symptom Improvement by Metabolic Modulators in Mecp2‐Mutant Mice
; Rett Syndrome; neurodevelopmental disorders; metabolism GO TO THE FULL PROTOCOL: PDF or HTML at Wiley Online Library
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