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- MCE
- HY-L063
- 2026年03月24日
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- 库存：
【化合物数量】282
- 供应商：
广州市左克生物
化学探针是一种高效、高选择性、高细胞渗透性的试剂，在基础生物学和应用生物学研究中都发挥着重要作用。高质量的化学探针可以充当生物学研究的基础工具，加深对靶标蛋白功能和机制的理解；可以用于开展药物作用新靶标的发现和确认研究；可以充当药物化合物合成优化的先导化合物结构。 MCE 收录了 [0] 个具有高效（对特定靶点的作用活性低于 100 nM）、高选择性（高于 10 倍以上选择性）、高细胞渗透性（细胞活性不高于10 μM）特性的化学探针，是靶点鉴定及机制研究的重要工具。
活性描述 & 特点
Biological Activity
• A unique collection of 283 chemical probes with high potency, selectivity and cell-permeability for high throughput screening (HTS) and high content screening (HCS).
• A useful tool for fundamental biological research and drug discovery.
• Structurally diverse, medicinally active, and cell permeable.
• Detailed compound information with structure, IC50, and brief introduction.
• Validated NMR and HPLC to ensure high purity and quality.
• All compounds are in stock and continuously updated.
产品详情
Product Details
Formulation:
A collection of 283 chemical probes supplied as pre-dissolved Solutions or Solid
Solution: 279 compounds supplied in 10 mM solution, 4 compounds supplied in 2 mM solution.
Layout:
96-well storage tube or 96-well plate: 1st and 12th column are left empty.
384-well plate: the first two columns and the last two columns are left empty.
Compounds with different concentrations or dissolved in different solvents will be put on separate plates. This way of layout may increase the number of plates because there could be three solvents and three concentrations.
If you have other requirements, please let us know.
Container:
96- or 384-well Plate with Peelable Foil Seal; 96-well Format Sample Storage Tube With Screw Cap and Optional 2D Barcode
Storage:
-80°C
Shipping:
Blue ice or dry ice
化合物库组成
Composition
Apoptosis(41)
Epigenetic Reader Domain(31)
Histone Methyltransferase(31)
Autophagy(24)
Bcl-2 Family(10)
CDK(9)
Histone Acetyltransferase(9)
JAK(7)
E1/E2/E3 Enzyme(6)
Free Fatty Acid Receptor(6)
Btk(5)
c-Met/HGFR(5)
ERK(5)
Histone Demethylase(5)
PARP(5)
PROTACs(5)
Src(5)
Aurora Kinase(4)
FGFR(4)
HIV(4)
p38 MAPK(4)
PAK(4)
PI3K(4)
Bacterial(3)
Bcr-Abl(3)
Checkpoint Kinase (Chk)(3)
DYRK(3)
EGFR(3)
FLT3(3)
HDAC(3)
HIF/HIF Prolyl-Hydroxylase(3)
MDM-2/p53(3)
Mps1(3)
Ras(3)
RIP kinase(3)
Sodium Channel(3)
TGF-β Receptor(3)
TRP Channel(3)
Wnt(3)
Akt(2)
AMPK(2)
CaMK(2)
Deubiquitinase(2)
Discoidin Domain Receptor(2)
DNA/RNA Synthesis(2)
Dopamine Receptor(2)
EBI2/GPR183(2)
Elastase(2)
FAAH(2)
FAK(2)
Fatty Acid Synthase (FASN)(2)
GnRH Receptor(2)
HSP(2)
IGF-1R(2)
Insulin Receptor(2)
Ligands for Target Protein for PROTAC(2)
LRRK2(2)
LXR(2)
MEK(2)
MMP(2)
mTOR(2)
NF-κB(2)
Phosphodiesterase (PDE)(2)
Potassium Channel(2)
Prostaglandin Receptor(2)
Syk(2)
Trk Receptor(2)
VEGFR(2)
Virus Protease(2)
YAP(2)
γ-secretase(2)
AAK1(1)
Acyltransferase(1)
Adrenergic Receptor(1)
Anaplastic lymphoma kinase (ALK)(1)
Androgen Receptor(1)
Antibiotic(1)
Antifolate(1)
ATM/ATR(1)
Beta-lactamase(1)
BMX Kinase(1)
c-Fms(1)
Caspase(1)
CCR(1)
CFTR(1)
CMV(1)
Complement System(1)
Cyclic GMP-AMP Synthase(1)
Cyclin G-associated Kinase (GAK)(1)
Cytochrome P450(1)
Dengue Virus(1)
Dihydroorotate Dehydrogenase(1)
EBV(1)
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文献和实验Using ChemBank to Probe Chemical Biology
measurements, and cell states. This unit demonstrates the use of ChemBank data to ask and answer questions relating to chemical biology and screening experiments contained within ChemBank. Curr. Protoc. Bioinform. 22:14.5.1?14.5.26. © 2008 by John Wiley & Sons
Historical Overview of Chemical Library Design
High-throughput chemistry (HTC) is approaching its 20-year anniversary. Since 1992, some 5,000 chemical libraries, prepared for the purpose of biological intestigation and drug discovery, have been published in the scientific literature
SCREENING A LAMBDA BACTERIOPHAGE GENOMIC LIBRARY WITH A DNA PROBE
Plate a bacteriophage library at about 30,000-50,000 pfus per 150mm Petri dish by adding an appropriate amount of bacteriophage to 500µl MgSO4-stored E.coli.Dilute bacteria,if needed(ex.VCS237 to A600=0.5).Incubate for 15 minutes at 37°C
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