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文献和实验In this chapter, a genetic approach is presented that leads to the isolation of mutants and to the identification of proteins involved in protein quality control and endoplasmic reticulum-associated degradation (ERAD). The method makes use
Nature Communications|压力对细胞有何好处?
所 Edward Avezov 博士领导的团队在 Nature Communications 杂志发表研究论文 Stress-induced protein disaggregation in the endoplasmic reticulum catalysed by BiP。该研究揭示,当细胞被要求生产大量的蛋白质时,它们会感到「压力」,这种「压力」通过拆开聚集体使其正确地折叠,有助于防止阿尔茨海默症中常见的蛋白质缠结的堆积。 若能寻找一种方法唤醒该机制,使细胞在压力状态下促使蛋白聚集体拆解并正确
The unfolded protein response (UPR) was originally identified as a signaling network coordinating adaptive and apoptotic responses to accumulation of unfolded proteins in the endoplasmic reticulum (ER). More recent work has shown that UPR
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