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- MCE
- HY-L020
- 2026年03月24日
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- 详细信息
- 文献和实验
- 技术资料
- 库存：
【化合物数量】521
- 供应商：
广州市左克生物
发育蛋白 Hedgehog、Notch 和 Wn t是调控多种组织中细胞命运、增殖、迁移和分化的关键因子。它们相关的信号通路在肿瘤中经常被激活，特别是在罕见的癌症干细胞亚群中。 Wnt 信号通路是动物体内一条保守的通路。Wnt 信号通路失调会对胚胎发育产生严重后果，现在人们已经充分认识到 Wnt 信号通路缺陷是导致包括癌症在内的许多人类疾病的原因之一。Hedgehog 信号通路与肿瘤发生有关，在多种癌症中异常激活。Notch 信号通路在动物中高度保守。它在细胞间通讯中起重要作用，并进一步调控胚胎发育。 MCE 可以提供 [0] 个 Wnt/Hedgehog/Notch 信号通路相关小分子化合物，是研究干细胞及筛选抗肿瘤药物的有用工具。
活性描述 & 特点
Biological Activity
• A unique collection of 555 small molecule inhibitors with biological activity used for Wnt/Hedgehog/Notch pathway research and screening.
• Targets include Notch, Gli, GSK-3, Hedgehog, Porcupine, sFRP-1, Smo, Wnt, β-catenin, etc.
• A useful tool for the research of Wnt/Hedgehog/Notch-related regulation and diseases.
• Bioactivity and safety confirmed by preclinical research and clinical trials. Some inhibitors have been approved by FDA.
• Structurally diverse, medicinally active, and cell permeable.
• More detailed compound information with structure, IC50, and brief introduction.
• NMR and HPLC validated to ensure high purity and quality.
• All compounds are in stock and continuously updated.
产品详情
Product Details
Formulation:
A collection of 555 Wnt/Hedgehog/Notch signaling related compounds supplied as pre-dissolved Solutions or Solid
Solution: 531 compounds supplied in 10 mM solution, 23 compounds supplied in 2 mM solution, 1 compounds supplied in 3 mg/mL solution.
Layout:
96-well storage tube or 96-well plate: 1st and 12th column are left empty.
384-well plate: the first two columns and the last two columns are left empty.
Compounds with different concentrations or dissolved in different solvents will be put on separate plates. This way of layout may increase the number of plates because there could be three solvents and three concentrations.
If you have other requirements, please let us know.
Container:
96- or 384-well Plate with Peelable Foil Seal; 96-well Format Sample Storage Tube With Screw Cap and Optional 2D Barcode
Storage:
-80°C
Shipping:
Blue ice or dry ice
化合物库组成
Composition
Wnt(159)
GSK-3(121)
β-catenin(97)
Casein Kinase(78)
Smo(32)
Notch(31)
Hedgehog(25)
Porcupine(8)
Gli(5)
sFRP-1(3)
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文献和实验protein c-myc and jagged1. Simultaneously, the Wnt and Notch signaling pathways were co-activated, as confirmed by the increased expression of β-catenin and notch1. Plasmids expressing Lef1 and ΔNLef1, a construct in which the β-catenin-binding domain
吧~1 基本图绘制呐~笔者整理出一份基础教程，为了照顾零基础的电脑盲同学，我们从安装 R 语言开始介绍。给大家两个网址，里面详细介绍了 R 语言 [2] 和 RStudio [3] 的安装。安装好后我们打开 RStudio：> setwd("D:/workdir/") #设置工作目录>install.packages(“ggplot2”) #安装 pheatmap 程序包> library(ggplot2) #加载 ggplot2 程序包> data 笔者找来一个数据集如下：进行完准备
Whole genome amplification protocol for ChIP-chip
of reverse crosslinked, QIAquick purified DNA is lyophilized and resuspended in 10µl of H2 0 (comment 1 and comment 2); Add 2µl 1X Library Preparation Buffer to 10µl of input material; Transfer samples to strip tubes or individual thin walled
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