Erythroferrone (human) ELISA K

Erythroferrone (human) ELISA Kit产品由Adipogen公司生产，产地是瑞士。该产品货号为AG-45B-0014-KI01，包装规格是96 wells。如需购买该产品，询问折扣价/货期/技术问题，请联系Adipogen授权代理商——欣博盛生物 

Erythroferrone (also called Myonectin, CTRP15 or Fam13B) is a member of CTRPs (C1q/TNF-related proteins), which are conserved paralogs of adiponectin containing collagen-like and globular C1q-like domains. Erythroferrone plays two different regulatory roles:

i) Erythroferrone (called Myonectin for this role) is a myokine abundantly expressed in skeletal muscle tissue, upregulated by voluntary exercise that is suppressed by fasting and induced by refeeding; it participates in the regulation of systemic lipid metabolism by promoting the clearance of nonesterified fatty acids (NEFA) from circulation. As a myokine, Erythroferrone/Myonectin acts as an endurance exercise-driven myokine which protects the heart from ischemic injury by reducing cardiomyocyte apoptosis and macrophage inflammatory response, and

ii) Erythroferrone is produced by erythroblasts after bleeding or EPO treatment and acts on hepatocytes to suppress hepcidin expression, resulting in increased release of iron from cellular iron stores. Erythroferrone acts on hepcidin by inhibiting members of the BMP-5, BMP-6 and BMP-7 subgroup of BMPs. Erythroferrone functions as erythroid modulator of iron metabolism and hemoglobin synthesis. Iron metabolism (including Hepcidin and Erythroferrone) is closely linked to viral infection (intrusion, replication) and might be an anitviral target (such as for SARS-CoV-2).

Levels of Erythroferrone measured by this ELISA Kit in serum and plasma correspond to mouse protein levels (~500ng/ml). Our Erythroferrone assay has been validated by the Swiss Laboratory for Doping Analyses in a recent publication, reporting that our assay can sensitively detect the stimulation of erythropoiesis, including erythropoiesis stimulating agents (ESA, such as Erythropoietin) abuse and blood withdrawal. Erythroferrone is a biomarker for different types of anemia, for cardiology and potentially also for metabolic diseases. 

Synonyms    CTRP15; Complement C1q Tumor Necrosis Factor-related Protein 15; Myonectin; FAM132B; ERFE
Product Type    Kit
Properties
Application Set    Quantitative ELISA
Specificity    
Detects human Erythroferrone [Myonectin; CTRP15; ERFE] in serum, plasma and cell culture supernatant.

Crossreactivity    Human
Quantity    
1 x 96 wells

Sensitivity    270pg/ml
Range    0.3125 to 20ng/ml
Sample Type    Cell Culture Supernatant
Plasma
Serum
Assay Type    Sandwich
Detection Type    Colorimetric
Other Product Data    
UniProt link Q4G0M1: Erythroferrone (human)

See our Erythroferrone Landing Page for important Information!

NOTE: Important Recommendation for Sample Dilution: Explanation & Hypothesis.

Accession Number    Q4G0M1
Shipping and Handling
Shipping    BLUE ICE
Short Term Storage    +4°C
Long Term Storage    +4°C
Handling Advice    After standard reconstitution, prepare aliquots and store at -20°C.
Avoid freeze/thaw cycles.
Plate and reagents should reach room temperature before use.
Use/Stability    12 months after the day of manufacturing. See expiry date on ELISA Kit box.