- ￥1280 - 1980
- YLKBIO
- YLK-KT2470D
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- 2026年02月20日
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- 详细信息
- 文献和实验
- 技术资料
- 供应商：
优利科（上海）生命科学有限公司
- 库存：
63
- 靶点：
详询
- 级别：
科研
- 目录编号：
/
- 克隆性：
多克隆
- 抗原来源：
详见说明书
- 保质期：
1年
- 抗体英文名：
Anti-phospho-IkB beta (Ser19)
- 抗体名：
phospho-IkB beta (Ser19) 抗体
- 标记物：
详询
- 宿主：
兔
- 适应物种：
/
- 免疫原：
见产品详情
- 亚型：
IgG
- 形态：
冻干或液体
- 应用范围：
见产品详情
- 保存条件：
-20℃
- 浓度：
1mg/ml
- 规格：
详询
| 英文名称 Anti-phospho-IkB beta (Ser19) |
| 中文名称 NF-kappa-B抑制子beta抗体 |
| 别 名 I kappa B beta; I-kappa-B-beta; IkappaBbeta; IKB beta; IkB-B; IkB-beta; IKBB; IKBB_HUMAN; IkBbeta; NF kappa BIB; NF-kappa-B inhibitor beta; NF-kappa-BIB; Nfkbib; Thyroid receptor interacting protein 9; Thyroid receptor-interacting protein 9; TR interacting protein 9; TR-interacting protein 9; TRIP-9; TRIP9. |
| 浓 度 1mg/1ml |
| 规 格 0.1ml/100μg |
| 抗体来源 Rabbit |
| 克隆类型 polyclonal |
| 交叉反应 Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit |
| 产品类型 一抗 |
研究领域 细胞生物 免疫学 染色质和核信号 信号转导 表观遗传学  |
| 蛋白分子量 predicted molecular weight: 38kDa |
| 性 状 Lyophilized or Liquid |
| 免 疫 原 KLH conjugated synthesised phosphopeptide derived from human NFKBIB around the phosphorylation site of Ser19 |
| 亚 型 IgG |
| 纯化方法 affinity purified by Protein A |
| 储 存 液 Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4 |
| 产品应用 WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 |
| （石蜡切片需做抗原修复） |
| not yet tested in other applications. |
| optimal dilutions/concentrations should be determined by the end user. |
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.  |
| Important Note This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 产品介绍 The protein encoded by this gene belongs to the NF-kappa-B inhibitor family, which inhibit NF-kappa-B by complexing with, and trapping it in the cytoplasm. Phosphorylation of serine residues on these proteins by kinases marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B, which translocates to the nucleus to function as a transcription factor. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Jul 2011]. |
| Function : Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. However, the unphosphorylated form resynthesized after cell stimulation is able to bind NF-kappa-B allowing its transport to the nucleus and protecting it to further NFKBIA-dependent inactivation. Association with inhibitor kappa B-interacting NKIRAS1 and NKIRAS2 prevent its phosphorylation rendering it more resistant to degradation, explaining its slower degradation. |
| Subunit : Interacts with THRB (via ligand-binding domain). Interacts with RELA and REL. Interacts with COMMD1 and inhibitor kappa B-interacting Ras-like NKIRAS1 and NKIRAS2. |
| Subcellular Location : Cytoplasm. Nucleus. |
| Tissue Specificity : Expressed in all tissues examined. |
| Post-translational modifications : Phosphorylated by RPS6KA1; followed by degradation. Interaction with NKIRAS1 and NKIRAS2 probably prevents phosphorylation. |
| Similarity : Belongs to the NF-kappa-B inhibitor family. |
| Contains 6 ANK repeats. |
Database links : UniProtKB/Swiss-Prot: Q15653.2 |
| Anti-WWOX （WW domain-containing oxidoreductase） 包含氧化还原酶的WW域抗体 |
| Mouse Anti-YERSINIA PESTIS Monoclonal Antibody 鼠抗鼠疫F1蛋白/鼠疫耶尔森氏菌荚膜抗原F1单克隆抗体 |
| anti-XIAP（X-linked Inhibitor of Apoptosis Protein） X-连锁凋亡蛋白/性连锁凋亡抑制蛋白抗体 |
| anti-XAF1（XIAP-associated factor 1） XIAP相关因子1抗体 |
| Anti-XYTC1（X-ray Repair Cross Complementing 1） X射线修复交叉互补蛋白/细胞碱基切除修复基因抗体 |
| Anti-ZCWCC1(Zinc finger CW-type coiled-coil domain protein 1) ZCWCC1抗体 |
| Anti-Z-DEVD-FMK(CASPASE3/CPP32 INHIBITOR W-3) CASPASE3凋亡抑制剂 |
| Anti-ZNF268 (zinc finger protein ZNF268)- middle (1b) 锌指脂蛋白-1b抗体 |
| Anti-ZNF268 (zinc finger protein ZNF268)- middle (1c) 锌指脂蛋白-1c抗体 |
| Anti-ZNF268 (zinc finger protein ZNF268)- N-terminal (1a) Anti-ZNF268 (zinc finger protein ZNF268)- N-terminal (1a) 锌指脂蛋白-1a抗体 |
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文献和实验相关实验
joan831 请教高手：ERK1/2与NF-kappa B两个信号通路关系如何？前者能激活后者吗？还有，若在文献中查到的某种细胞类型中（比如单核细胞）中ERK1/2与NF-kappa B两个信号通路的关系是否也适用于其他细胞类型（比如肾系膜细胞）？谢谢！ lijinbaobao 前者能激活后者，应该在其他的细胞类型中也适用。 lwjssry 一种细胞的信号通路除非你证明了也存在于另一
The nuclear factor-kappa B (NFκB) family of transcription factors has emerged as a signaling pathway that figures prominently in a cell’s initial response to a plethora of inflammatory stimuli. Modified lipids, oxidative stress, bacterial
owen79 各位大侠好，小弟愚问一下，我想测定NF-KB活化后细胞核内的量，这需要提取核蛋白，但是蛋白量太少，提取出来能否测出NF-KB啊！thank you ! ronaldo_zj 1. 通过提取细胞核、细胞浆内的蛋白来行western blot检测NF-kappa B 的表达情况是可以的，因为很多时候是通过NF-kappa B转位来实现活化的，所以提取的时候我不知道楼主是自己配制试剂提取还是用试剂盒提取的，我建议
NF-kappa-B抑制子beta抗体
￥1280 - 1980
